Amlodipine

195 interactions 821 cited references
Also sold as: Amvaz® Katerzia Katerzia® Norliqva Norvasc Norvasc® Sdamlo
About Amlodipine

Amlodipine is a calcium channel blocker used to treat high blood pressure, chest pain, and narrowing of heart blood vessels. Read the full Amlodipine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Amlodipine Lonafarnib Zokinvy Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Amlodipine Lopinavir Reduced amLODIPine exposure Details Amlodipine Lorlatinib Lorbrena Reduced amLODIPine exposure Details Amlodipine Lumacaftor Reduced amLODIPine exposure Details Amlodipine Melphalan Alkeran An increased risk of severe hypotension Details Amlodipine Methylergonovine Methergine Increased methylergonovine exposure Details Amlodipine Methylprednisolone Depo-Medrol Reduced amLODIPine exposure Details Amlodipine Mifepristone Korlym Increased miFEPRIStone exposure, an increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Mitapivat Aqvesme Reduced amLODIPine exposure Details Amlodipine Mitotane Lysodren Reduced amLODIPine exposure Details Amlodipine Mobocertinib Exkivity Reduced amLODIPine exposure Details Amlodipine Modafinil Provigil Reduced amLODIPine exposure Details Amlodipine Nafcillin Reduced amLODIPine exposure Details Amlodipine Nefazodone Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Nelfinavir Viracept Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Netupitant Increased exposure of CYP3A4 substrate Details Amlodipine Nevirapine Viramune Reduced amLODIPine exposure Details Amlodipine Nifedipine Adalat® Increased NIFEdipine exposure Details Amlodipine Nilotinib Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Nirmatrelvir Increased calcium channel blocker exposure and an increased risk of hypotension Details Amlodipine Nirogacestat Ogsiveo Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Omaveloxolone Skyclarys Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Amlodipine Oritavancin Reduced amLODIPine exposure Details Amlodipine Oxcarbazepine Oxtellar Reduced amLODIPine exposure Details Amlodipine Paritaprevir Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Pexidartinib Turalio Reduced amLODIPine exposure Details Amlodipine Phenobarbital Fidoquel Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Amlodipine Phenytoin Dilantin Reduced amLODIPine exposure Details Amlodipine Pimozide Increased pimozide exposure Details Amlodipine Pioglitazone Actos Reduced amLODIPine exposure Details Amlodipine Piperaquine Increased exposure of piperaquine and CYP3A4 substrates Details Amlodipine Pitolisant Wakix Reduced amLODIPine exposure Details Amlodipine Ponesimod Ponvory An increased risk of bradycardia and heart block Details Amlodipine Posaconazole Noxafil Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Prednisone Deltasone Reduced amLODIPine exposure Details Amlodipine Pretomanid Reduced amLODIPine exposure Details Amlodipine Primidone Mysoline Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Amlodipine Quercetin Reduced amLODIPine exposure Details Amlodipine Raltegravir Isentress Reduced amLODIPine exposure Details

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