Amodiaquine and Abiraterone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Abiraterone
Amodiaquine
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure to amodiaquine
Interaction Deep Dive
Concomitant use of abiraterone, a strong CYP2C8 inhibitor1, and amodiaquine, a CYP2C8 substrate 23, may cause increased amodiaquine exposure. When abiraterone and amodiaquine are administered concurrently, patients should be monitored closely for amodiaquine toxicity 1.
Why it happens (mechanism)
Inhibition of CYP2C8-mediated metabolism of amodiaquine by abiraterone
Common questions
Can I take Amodiaquine and Abiraterone together?
Increased exposure to amodiaquine Always confirm with your pharmacist or prescriber before making any change.
How serious is the Amodiaquine and Abiraterone interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Amodiaquine or Abiraterone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (3)
- Product Information: ZYTIGA(R) oral tablets, abiraterone acetate oral tablets. Janssen Biotech, Inc. (per FDA), Horsham, PA, 2012. DailyMed
- Flockhart DA: P450 Drug Interaction Table: Abbreviated "Clinically Relevant" Table. Indiana University School of Medicine. Indianapolis, IN. 2012.
- Flockhart DA: P450 Drug Interaction Table. Indiana University School of Medicine. Indianapolis, IN. 2012.
Keep reading about Abiraterone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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