Amoxicillin

Name: Amoxicillin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

68 interactions 441 cited references

Also sold as: Amoxi Drop Amoxi-tabs Amoxil® Amoxil® Pediatric Drops Biomox Dispermox® Larotid® Suspension Moxatag Moxtag® Polymox® Suspension Talicia (as a combination product containing Amoxicillin, Omeprazole, Rifabutin) Trimox Trimox® Trimox® Pediatric Drops Wymox®

About Amoxicillin

Amoxicillin is a penicillin-like antibiotic used to treat bacterial infections like pneumonia, bronchitis, and ear, nose, throat, urinary tract, and skin infections. Read the full Amoxicillin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acenocoumarol Chlortetracycline Cholera Vaccine, Live Coumarin Demeclocycline Minocycline Topical

48 Major 5 Moderate 15 Minor

All (68) Major (48) Moderate (5) Minor (15)

Major

Amoxicillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Amoxicillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Amoxicillin Estradiol Topical Divigel Reduced efficacy of oral contraceptive Details Amoxicillin Estradiol Transdermal Patch Alora® Reduced efficacy of oral contraceptive Details Amoxicillin Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Amoxicillin Levonorgestrel Intrauterine System Kyleena Reduced efficacy of oral contraceptive Details Amoxicillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Amoxicillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.