Amoxicillin

68 interactions 441 cited references
Also sold as: Amoxi Drop Amoxi-tabs Amoxil® Amoxil® Pediatric Drops Biomox Dispermox® Larotid® Suspension Moxatag Moxtag® Polymox® Suspension Talicia (as a combination product containing Amoxicillin, Omeprazole, Rifabutin) Trimox Trimox® Trimox® Pediatric Drops Wymox®
About Amoxicillin

Amoxicillin is a penicillin-like antibiotic used to treat bacterial infections like pneumonia, bronchitis, and ear, nose, throat, urinary tract, and skin infections. Read the full Amoxicillin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acenocoumarol Chlortetracycline Cholera Vaccine, Live Coumarin Demeclocycline Minocycline Topical
48 Major 5 Moderate 15 Minor
All (68) Major (48) Moderate (5) Minor (15)

Major

Amoxicillin Acenocoumarol Increased INR and increased risk of bleeding Details Amoxicillin Chlortetracycline Decreased antibacterial effectiveness Details Amoxicillin Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Amoxicillin Coumarin Increased INR and increased risk of bleeding Details Amoxicillin Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Amoxicillin Desogestrel Reduced efficacy of oral contraceptive Details Amoxicillin Dicumarol Increased INR and increased risk of bleeding Details Amoxicillin Dienogest Reduced efficacy of oral contraceptive Details Amoxicillin Doxycycline Acticlate Decreased antibacterial effectiveness Details Amoxicillin Drospirenone Reduced efficacy of oral contraceptive Details Amoxicillin Eravacycline Xerava Decreased antibacterial effectiveness Details Amoxicillin Estetrol Reduced efficacy of oral contraceptive Details Amoxicillin Estradiol Delestrogen Reduced efficacy of oral contraceptive Details Amoxicillin Ethinyl Estradiol Reduced efficacy of oral contraceptive Details Amoxicillin Ethynodiol Reduced efficacy of oral contraceptive Details Amoxicillin Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Amoxicillin Gestodene Reduced efficacy of oral contraceptive Details Amoxicillin Levonorgestrel After banger Reduced efficacy of oral contraceptive Details Amoxicillin Lymecycline Decreased antibacterial effectiveness Details Amoxicillin Meclocycline Decreased antibacterial effectiveness Details Amoxicillin Mestranol Reduced efficacy of oral contraceptive Details Amoxicillin Methacycline Decreased antibacterial effectiveness Details Amoxicillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Amoxicillin Minocycline Amzeeq Decreased antibacterial effectiveness Details Amoxicillin Mycophenolate Mofetil Decreased mycophenolic acid plasma exposure Details Amoxicillin Nomegestrol Reduced efficacy of oral contraceptive Details Amoxicillin Norethindrone Aygestin Reduced efficacy of oral contraceptive Details Amoxicillin Norgestimate Reduced efficacy of oral contraceptive Details Amoxicillin Norgestrel Reduced efficacy of oral contraceptive Details Amoxicillin Oxytetracycline Decreased antibacterial effectiveness Details Amoxicillin Phenindione Increased INR and increased risk of bleeding Details Amoxicillin Phenprocoumon Increased INR and increased risk of bleeding Details Amoxicillin Probenecid Prolonged and increased amoxicillin exposure Details Amoxicillin Rolitetracycline Decreased antibacterial effectiveness Details Amoxicillin Sarecycline Seysara Decreased antibacterial effectiveness Details Amoxicillin Sulfasalazine Azulfidine An increased risk of drug reaction with eosinophilia and systemic symptoms Details Amoxicillin Tetracycline Achromycin V® Decreased antibacterial effectiveness Details Amoxicillin Tigecycline Tygacil Decreased antibacterial effectiveness Details Amoxicillin Venlafaxine An increased risk of serotonin syndrome Details Amoxicillin Warfarin Coumadin Increased INR and increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.