Ampicillin

72 interactions 1 explained in plain English 590 cited references
Also sold as: Amcill® Omnipen® Penbritin® Pfizerpen® Polycillin® Polyflex Principen® Totacillin®
About Ampicillin

Ampicillin is a penicillin antibiotic used to treat bacterial infections including meningitis, throat, sinus, lung, and urinary tract infections. Read the full Ampicillin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amifampridine Bupropion Chlortetracycline Cholera Vaccine, Live Minocycline Topical Levonorgestrel Intrauterine System
44 Major 12 Moderate 16 Minor
All (72) Major (44) Moderate (12) Minor (16)

Major

Ampicillin Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Ampicillin Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Ampicillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ampicillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details

Moderate

Ampicillin Chloroquine Aralen® Decreased chloroquine bioavailability Details Ampicillin Dexlansoprazole Dexilant Reduced ampicillin bioavailability Details Ampicillin Entacapone Comtan An increased risk of enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Ampicillin Khat Reduced effectiveness of ampicillin Details Ampicillin Lansoprazole Prevacid Loss of ampicillin efficacy Details Ampicillin Lanthanum Carbonate Fosrenol Reduced ampicillin bioavailability Details Ampicillin Lixisenatide Delayed therapeutic effect Details Ampicillin Pantoprazole Protonix Loss of ampicillin efficacy Details Ampicillin Rabeprazole Aciphex Loss of ampicillin efficacy Details Ampicillin Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details Ampicillin Lanthanum Fosrenol® Reduced ampicillin bioavailability Details Ampicillin Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

Minor

Ampicillin Amikacin Injection Amikin® Loss of aminoglycoside efficacy Details Ampicillin Amikacin Oral Inhalation Arikayce Loss of aminoglycoside efficacy Details Ampicillin Amikacin Loss of aminoglycoside efficacy Details Ampicillin Atenolol Tenormin Explained Decreased atenolol effectiveness Details Ampicillin Dibekacin Loss of aminoglycoside efficacy Details Ampicillin Framycetin Loss of aminoglycoside efficacy Details Ampicillin Gentamicin Loss of aminoglycoside efficacy Details Ampicillin Isepamicin Loss of aminoglycoside efficacy Details Ampicillin Kanamycin Loss of aminoglycoside efficacy Details Ampicillin Neomycin Loss of aminoglycoside efficacy Details Ampicillin Netilmicin Loss of aminoglycoside efficacy Details Ampicillin Streptomycin Loss of aminoglycoside efficacy Details Ampicillin Tobramycin Bethkis Loss of aminoglycoside efficacy Details Ampicillin Gentamicin Injection Garamycin® I.V. Loss of aminoglycoside efficacy Details Ampicillin Gentamicin Ophthalmic Garamycin® Ophthalmic Loss of aminoglycoside efficacy Details Ampicillin Gentamicin Topical Garamycin® Loss of aminoglycoside efficacy Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.