Ampicillin

72 interactions 1 explained in plain English 590 cited references

Also sold as: Amcill® Omnipen® Penbritin® Pfizerpen® Polycillin® Polyflex Principen® Totacillin®

About Ampicillin

Ampicillin is a penicillin antibiotic used to treat bacterial infections including meningitis, throat, sinus, lung, and urinary tract infections. Read the full Ampicillin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amifampridine Bupropion Chlortetracycline Cholera Vaccine, Live Minocycline Topical Levonorgestrel Intrauterine System

44 Major 12 Moderate 16 Minor

All (72) Major (44) Moderate (12) Minor (16)

Major

Ampicillin Amifampridine Increased risk of seizures Details Ampicillin Bupropion Aplenzin Increased risk of seizures Details Ampicillin Chlortetracycline Decreased antibacterial effectiveness Details Ampicillin Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Ampicillin Clomipramine Anafranil Increased risk of seizures Details Ampicillin Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Ampicillin Desogestrel Decreased contraceptive effectiveness Details Ampicillin Dienogest Decreased contraceptive effectiveness Details Ampicillin Donepezil Adlarity Reduced seizure threshold Details Ampicillin Doxycycline Acticlate Decreased antibacterial effectiveness Details Ampicillin Drospirenone Decreased contraceptive effectiveness Details Ampicillin Eravacycline Xerava Decreased antibacterial effectiveness Details Ampicillin Estradiol Delestrogen Decreased contraceptive effectiveness Details Ampicillin Ethinyl Estradiol Decreased contraceptive effectiveness Details Ampicillin Ethynodiol Decreased contraceptive effectiveness Details Ampicillin Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Ampicillin Gestodene Decreased contraceptive effectiveness Details Ampicillin Hydroxychloroquine Plaquenil Reduced hydroxychloroquine bioavailability and an increased risk of seizures Details Ampicillin Levonorgestrel After banger Decreased contraceptive effectiveness Details Ampicillin Lymecycline Decreased antibacterial effectiveness Details Ampicillin Meclocycline Decreased antibacterial effectiveness Details Ampicillin Mestranol Decreased contraceptive effectiveness Details Ampicillin Methacycline Decreased antibacterial effectiveness Details Ampicillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ampicillin Minocycline Amzeeq Decreased antibacterial effectiveness Details Ampicillin Nomegestrol Decreased contraceptive effectiveness Details Ampicillin Norethindrone Aygestin Decreased contraceptive effectiveness Details Ampicillin Norgestimate Decreased contraceptive effectiveness Details Ampicillin Norgestrel Decreased contraceptive effectiveness Details Ampicillin Oxytetracycline Decreased antibacterial effectiveness Details Ampicillin Rolitetracycline Decreased antibacterial effectiveness Details Ampicillin Sarecycline Seysara Decreased antibacterial effectiveness Details Ampicillin Tetracycline Achromycin V® Decreased antibacterial effectiveness Details Ampicillin Tigecycline Tygacil Decreased antibacterial effectiveness Details Ampicillin Tramadol ConZip An increased risk of seizure Details Ampicillin Warfarin Coumadin An increased risk of bleeding Details Ampicillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Ampicillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Ampicillin Estradiol Topical Divigel Decreased contraceptive effectiveness Details Ampicillin Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.