Anagrelide

434 interactions 313 cited references

Also sold as: Agrylin Agrylin®

About Anagrelide

Anagrelide is used to decrease the number of platelets (a type of blood cell that is needed to control bleeding) in the blood of patients who have a bone marrow disorder, in which the body makes too many of one or more types of blood cells, such as essential thrombocythemia (condition in which the body makes too many p… Read the full Anagrelide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Bepridil Mesoridazine Abrocitinib Pimozide Levoketoconazole

15 Contraindicated 376 Major 41 Moderate 2 Minor

All (434) Contraindicated (15) Major (376) Moderate (41) Minor (2)

Major

Anagrelide Lapatinib Tykerb Increased risk of QT interval prolongation Details Anagrelide Lefamulin Xenleta Increased risk of QT interval prolongation Details Anagrelide Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Anagrelide Lepirudin Increased risk of bleeding Details Anagrelide Leuprolide Eligard Increased risk of QT interval prolongation Details Anagrelide Levofloxacin Levaquin Increased anagrelide exposure and increased risk of QT interval prolongation Details Anagrelide Levomilnacipran An increased risk of bleeding Details Anagrelide Lofexidine Increased risk of QT interval prolongation Details Anagrelide Lomefloxacin Increased anagrelide exposure Details Anagrelide Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Anagrelide Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Anagrelide Lornoxicam An increased risk of bleeding Details Anagrelide Loxoprofen An increased risk of bleeding Details Anagrelide Lumefantrine Increased risk of QT interval prolongation Details Anagrelide Lumiracoxib An increased risk of bleeding Details Anagrelide Macimorelin Increased risk of QT interval prolongation Details Anagrelide Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Anagrelide Meclofenamate Meclodium® An increased risk of bleeding Details Anagrelide Mefenamic Acid Ponstel® An increased risk of bleeding Details Anagrelide Mefloquine Lariam® Increased risk of QT interval prolongation Details Anagrelide Meloxicam Alloxate An increased risk of bleeding Details Anagrelide Melphalan Alkeran An increased risk of bleeding Details Anagrelide Methadone Diskets Increased risk of QT interval prolongation Details Anagrelide Methoxsalen Increased anagrelide exposure Details Anagrelide Metronidazole Flagyl An increased risk of QT interval prolongation Details Anagrelide Mexiletine Mexitil® Increased anagrelide exposure Details Anagrelide Mibefradil Increased anagrelide exposure Details Anagrelide Mifepristone Korlym Increased risk of QT interval prolongation Details Anagrelide Milnacipran Savella An increased risk of bleeding Details Anagrelide Milrinone Increased bleeding risk; additive vasodilation; increased risk of tachycardia, palpitations, and heart failure Details Anagrelide Milsaperidone An increased risk of QT interval prolongation Details Anagrelide Mirtazapine Mirataz Increased risk of QT interval prolongation and torsades de pointes Details Anagrelide Mizolastine Increased risk of QT interval prolongation Details Anagrelide Mobocertinib Exkivity An increased risk of QT interval prolongation Details Anagrelide Morniflumate An increased risk of bleeding Details Anagrelide Moxifloxacin Avelox Increased anagrelide exposure and increased risk of QT interval prolongation Details Anagrelide Nabumetone Relafen An increased risk of bleeding Details Anagrelide Nadifloxacin Increased anagrelide exposure Details Anagrelide Nadroparin Increased risk of bleeding Details Anagrelide Naproxen Aleve An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.