Aprepitant

71 interactions 6 explained in plain English
Also sold as: Aponvie Cinvanti Emend
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Olaparib Infigratinib Budesonide Oral Inhalation Olutasidenib Ibrutinib
55 Major 16 Moderate
All (71) Major (55) Moderate (16)

Major

Aprepitant Letermovir Injection Prevymis Increased aprepitant exposure Details Aprepitant Levonorgestrel After banger Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Aprepitant Levonorgestrel Intrauterine System Kyleena Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Aprepitant Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Aprepitant Lumateperone Caplyta Altered (reduced/increased) lumateperone exposure and an increased risk of lumateperone-related adverse reaction Details Aprepitant Lurasidone Latuda Increased lurasidone exposure Details Aprepitant Lurbinectedin Injection Zepzelca Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Aprepitant Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Aprepitant Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Aprepitant Methylergonovine Methergine Increased methylergonovine exposure and an increased risk of vasospasm, cerebral ischemia and/or ischemia of extremities Details Aprepitant Mitapivat Aqvesme Increased mitapivat exposure Details Aprepitant Naloxegol Movantik Increased naloxegol exposure Details Aprepitant Nifedipine Adalat® Increased NIFEdipine exposure and reduced NIFEdipine exposure Details Aprepitant Olaparib Lynparza Increased olaparib exposure Details Aprepitant Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details

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