Drug Interaction Report

Aripiprazole Injection and Haloperidol: Interaction Details

A pharmacist-reviewed analysis of the Aripiprazole Injection and Haloperidol interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Haloperidol

No brand names on record
+

Aripiprazole Injection

Abilify Abilify Maintena® Abilify® Aristad Initio® Aristada® Opipza
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Jul 11, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 347 documented Aripiprazole Injection interactions, 316 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of QT interval prolongation and an increased risk of CNS depression

Interaction Deep Dive

Concurrent use of haloperidol may be capable of potentiating CNS depressants. Hence concomitant use of haloperidol and ARIPiprazole or ARIPiprazole lauroxil (a prodrug of ARIPiprazole) (CNS depressant) may increase the risk of CNS depression6. Concomitant use of ARIPiprazole or ARIPiprazole lauroxil (a prodrug of ARIPiprazole) and other QT prolonging agents may cause QTc interval prolongation 23145. Although cases have been reported even in the absence of predisposing factors, exert caution with the concomitant use of haloperidol and other drugs that prolong QT 7.

Why it happens (mechanism)

Additive QT interval prolongation; additive CNS depression

Common questions

Can I take Aripiprazole Injection and Haloperidol together?

An increased risk of QT interval prolongation and an increased risk of CNS depression Always confirm with your pharmacist or prescriber before making any change.

How serious is the Aripiprazole Injection and Haloperidol interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Aripiprazole Injection or Haloperidol need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (7)

  1. Product Information: ABILIFY ASIMTUFII(R) intramuscular extended-release suspension, aripiprazole intramuscular extended-release suspension. Otsuka America Pharmaceutical Inc (per FDA), Rockville, MD, 2023.
  2. Product Information: ABILIFY(R) oral tablets, oral solution, intramuscular injection, aripiprazole oral tablets, oral solution, intramuscular injection. Otsuka America Pharmaceutical Inc (per FDA), Rockville, MD, 2022. DailyMed
  3. Product Information: ABILIFY MAINTENA(R) intramuscular extended-release injection, aripiprazole intramuscular extended-release injection. Otsuka America Pharmaceutical Inc (per FDA), Rockville, MD, 2020.
  4. Product Information: ARISTADA(R) intramuscular extended-release injection, aripiprazole lauroxil intramuscular extended-release injection. Alkermes Inc (per FDA), Waltham, MA, 2018.
  5. Product Information: ARISTADA INITIO (R) intramuscular extended-release injection, aripiprazole lauroxil intramuscular extended-release injection. Alkermes, Inc (per manufacturer), Waltham, MA, 2020.
  6. Product Information: Haloperidol oral solution, haloperidol oral solution. Advagen Pharma Ltd. (per DailyMed), East Windsor, NJ, 2024. DailyMed
  7. Product Information: HALDOL(R) Decanoate 100 intramuscular injection, haloperidol decanoate intramuscular injection. Janssen Pharmaceuticals Inc (per FDA), Titusville, NJ, 2025.
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Haloperidol

Keep reading about Haloperidol

All Haloperidol interactions (126)
Also serious with: Metoclopramide Injection Ketoconazole Topical Metoclopramide Nasal Spray Cetirizine Injection
Aripiprazole Injection

Keep reading about Aripiprazole Injection

All Aripiprazole Injection interactions (347) Aripiprazole Injection drug information
Also serious with: Mavorixafor Mesoridazine Metoclopramide Pimozide
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Haloperidol + Activated Charcoal American Hellebore Arsenic Cesium Ephedra Grapefruit Indian Snakeroot Rauvolfia Vomitoria + 203 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.