Aripiprazole Injection

347 interactions 801 cited references

Also sold as: Abilify Abilify Maintena® Abilify® Aristad Initio® Aristada® Opipza

About Aripiprazole Injection

Aripiprazole extended-release injection (Abilify Maintena, Aristada, Aristada Initio) is used alone or in combination with other aripiprazole preparations to treat schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Aripiprazole ext… Read the full Aripiprazole Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Mesoridazine Metoclopramide Pimozide Piperaquine Posaconazole

20 Contraindicated 316 Major 11 Moderate

All (347) Contraindicated (20) Major (316) Moderate (11)

Major

Aripiprazole Injection Pazopanib Votrient An increased risk of QT interval prolongation Details Aripiprazole Injection Pentamidine NebuPent An increased risk of QT interval prolongation Details Aripiprazole Injection Periciazine Risk of enhanced CNS depression Details Aripiprazole Injection Perphenazine An increased risk of QT interval prolongation Details Aripiprazole Injection Phenobarbital Fidoquel An increased risk of QT interval prolongation, an increased risk of CNS depression, reduced ARIPiprazole exposure and reduced effi... Details Aripiprazole Injection Phenytoin Dilantin Reduced ARIPiprazole exposure Details Aripiprazole Injection Pimavanserin Nuplazid An increased risk of QT interval prolongation Details Aripiprazole Injection Pinazepam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Pipamperone An increased risk of QT interval prolongation Details Aripiprazole Injection Pitolisant Wakix Increased risk of QT interval prolongation Details Aripiprazole Injection Ponesimod Ponvory An increased risk of QT interval prolongation Details Aripiprazole Injection Potassium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Aripiprazole Injection Prazepam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Pregabalin Bonqat An increased risk of respiratory depression Details Aripiprazole Injection Primidone Mysoline An increased risk of QT interval prolongation, an increased risk of CNS depression, reduced ARIPiprazole exposure and reduced effi... Details Aripiprazole Injection Probucol An increased risk of QT interval prolongation Details Aripiprazole Injection Procainamide Procan® An increased risk of QT interval prolongation Details Aripiprazole Injection Prochlorperazine An increased risk of QT interval prolongation Details Aripiprazole Injection Promethazine Phenadoz Increased risk of respiratory, profound sedation, hypotension, coma, death and an increased risk of QT prolongation Details Aripiprazole Injection Propafenone Rythmol An increased risk of QT interval prolongation Details Aripiprazole Injection Protriptyline An increased risk of QT interval prolongation Details Aripiprazole Injection Quazepam Doral An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Quetiapine Seroquel An increased risk of QT interval prolongation Details Aripiprazole Injection Quinidine Cardioquin® Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Quinine An increased risk of QT interval prolongation Details Aripiprazole Injection Quizartinib Vanflyta An increased risk of QT interval prolongation Details Aripiprazole Injection Ranolazine Aspruzyo Increased ARIPiprazole or ARIPiprazole lauroxil (a prodrug of ARIPiprazole) exposure and an increased risk of QT interval prolonga... Details Aripiprazole Injection Relacorilant Lifyorli Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Details Aripiprazole Injection Relugolix Orgovyx Increased risk of QT interval prolongation Details Aripiprazole Injection Remifentanil Increased risk of CNS depression and an increased risk of hypotension Details Aripiprazole Injection Remimazolam Byfavo Increased risk of profound sedation, respiratory depression, coma, and death Details Aripiprazole Injection Revumenib Revuforj An increased risk of QT interval prolongation Details Aripiprazole Injection Ribociclib Kisqali Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Rifampin Rifadin Reduced ARIPiprazole exposure Details Aripiprazole Injection Rifapentine Priftin Reduced ARIPiprazole exposure Details Aripiprazole Injection Rilpivirine Edurant An increased risk of QT interval prolongation Details Aripiprazole Injection Risperidone Perseris An increased risk of QT interval prolongation Details Aripiprazole Injection Ritonavir Norvir Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Ropeginterferon Alfa-2B-Njft Besremi Increased risk of sedation Details Aripiprazole Injection Scopolamine Pamine Increased or potentiated scopolamine effects and an increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.