Aripiprazole

86 interactions 6 explained in plain English

Also sold as: Abilify Opipza

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Ketoconazole Topical Abametapir Oxaliplatin Injection Glasdegib

3 Contraindicated 82 Major 1 Moderate

All (86) Contraindicated (3) Major (82) Moderate (1)

Major

Aripiprazole Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Aripiprazole Fostemsavir Rukobia Increased risk of torsade de pointes Details Aripiprazole Galantamine Razadyne An increased risk of QT interval prolongation Details Aripiprazole Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Aripiprazole Gemifloxacin Factive An increased risk of QT interval prolongation Details Aripiprazole Glasdegib Daurismo Increased risk of QT interval prolongation Details Aripiprazole Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Aripiprazole Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Aripiprazole Granisetron Injection Granisol An increased risk of QT interval prolongation Details Aripiprazole Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Aripiprazole Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Aripiprazole Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Aripiprazole Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Aripiprazole Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Aripiprazole Ivabradine Corlanor An increased risk of QT interval prolongation Details Aripiprazole Lacosamide Injection Motpoly An increased risk of CNS depression Details Aripiprazole Lefamulin Xenleta Increased risk of QT interval prolongation Details Aripiprazole Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Aripiprazole Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Aripiprazole Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Aripiprazole Levofloxacin Levaquin An increased risk of QT interval prolongation Details Aripiprazole Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Aripiprazole Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Aripiprazole Mefloquine Lariam® An increased risk of QT interval prolongation Details Aripiprazole Metronidazole Flagyl An increased risk of QT interval prolongation Details Aripiprazole Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Aripiprazole Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Aripiprazole Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Aripiprazole Midazolam Nasal Spray Nayzilam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Midazolam Injection Nayzilam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Aripiprazole Moxifloxacin Avelox An increased risk of QT interval prolongation Details Aripiprazole Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Aripiprazole Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Aripiprazole Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Aripiprazole Octreotide Bynfezia An increased risk of QT interval prolongation Details Aripiprazole Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Aripiprazole Ofloxacin Floxin® An increased risk of QT interval prolongation Details Aripiprazole Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Aripiprazole Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.