Aripiprazole

86 interactions 6 explained in plain English

Also sold as: Abilify Opipza

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Ketoconazole Topical Abametapir Oxaliplatin Injection Glasdegib

3 Contraindicated 82 Major 1 Moderate

All (86) Contraindicated (3) Major (82) Moderate (1)

Contraindicated

Aripiprazole Ketoconazole Topical Extina® Foam Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Aripiprazole Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Aripiprazole Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Aripiprazole Abametapir Explained Increased exposure of CYP3A4 substrate Details Aripiprazole Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Aripiprazole Sertraline Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Aripiprazole Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Aripiprazole Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Aripiprazole Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Aripiprazole Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Aripiprazole Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Aripiprazole Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Aripiprazole Azithromycin AzaSite An increased risk of QT interval prolongation Details Aripiprazole Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Aripiprazole Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Aripiprazole Alfuzosin UroXatral An increased risk of QT interval prolongation Details Aripiprazole Anagrelide Agrylin An increased risk of QT interval prolongation Details Aripiprazole Bedaquiline Sirturo An increased risk of QT interval prolongation Details Aripiprazole Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Aripiprazole Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Aripiprazole Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Aripiprazole Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Aripiprazole Chloroquine Aralen® An increased risk of QT interval prolongation Details Aripiprazole Dacomitinib Vizimpro Increased ARIPiprazole exposure Details Aripiprazole Dasatinib Phyrago An increased risk of QT interval prolongation Details Aripiprazole Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Aripiprazole Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Aripiprazole Diazepam Nasal Spray Valtoco Increased risk of CNS depression and orthostatic hypotension Details Aripiprazole Diazepam Rectal Diastat Increased risk of CNS depression and orthostatic hypotension Details Aripiprazole Disopyramide Norpace An increased risk of QT interval prolongation Details Aripiprazole Dofetilide Tikosyn An increased risk of QT interval prolongation Details Aripiprazole Dolasetron Anzemet An increased risk of QT interval prolongation Details Aripiprazole Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Aripiprazole Encorafenib Braftovi Reduced ARIPiprazole or ARIPiprazole lauroxil (prodrug of ARIPiprazole) exposure and an increased risk of QT interval prolongation Details Aripiprazole Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Aripiprazole Eribulin Injection Halaven An increased risk of QT interval prolongation Details Aripiprazole Esketamine Nasal Spray Spravato Increased risk of sedation Details Aripiprazole Famotidine Calmicid An increased risk of QT interval prolongation Details Aripiprazole Famotidine Injection Calmicid An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.