Drug Interaction Report

Aripiprazole and Cabergoline: Interaction Details

Name: Aripiprazole and Cabergoline Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Aripiprazole and Cabergoline interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Aripiprazole

Abilify Opipza

Cabergoline

Dostinex®

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Jul 11, 2026

Editorial policy · Data sources

Interaction severity

Major

Potentially serious — often needs a change or close monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 86 documented Aripiprazole interactions, 82 are rated major — including this one.

Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.

Onset

rapid

Evidence

theoretical

Severity

Major

What happens

Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors

Interaction Deep Dive

Concomitant use of cabergoline and dopamine-2 receptor antagonist is not recommended as it may reduce efficacy of cabergoline and dopamine-2 receptors¹.

Why it happens (mechanism)

Pharmacologic antagonism effect on dopamine-2 receptors

Common questions

Can I take Aripiprazole and Cabergoline together?

Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Always confirm with your pharmacist or prescriber before making any change.

How serious is the Aripiprazole and Cabergoline interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Aripiprazole or Cabergoline need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there a safer alternative to one of these medications for me?

References (1)

Product Information: DOSTINEX oral tablets, cabergoline oral tablets. Pharmacia & Upjohn Company (per FDA), New York, NY, 2025. DailyMed

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Aripiprazole

Keep reading about Aripiprazole

All Aripiprazole interactions (86)

Also serious with: Metoclopramide Nasal Spray Ketoconazole Topical Metoclopramide Injection Abametapir

Cabergoline

Keep reading about Cabergoline

All Cabergoline interactions (71) Cabergoline drug information

Also serious with: Sulpiride Metoclopramide Nasal Spray Amisulpride Acetophenazine

Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Aripiprazole + 1,4-butanediol Activated Charcoal American Hellebore Arsenic Beer Cesium Ephedra Gamma-hydroxybutyrate (ghb) + 242 more

Cabergoline + Activated Charcoal Coffee Charcoal European Mandrake Glucomannan Guar Gum Gum Arabic Slippery Elm Tragacanth + 9 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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A message from HelloPharmacist

About our interaction database: depth, not breadth

HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.