Arsenic Trioxide Injection and Fingolimod: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Arsenic Trioxide Injection
Fingolimod
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of QT interval prolongation
Interaction Deep Dive
Initiating fingolimod therapy may decrease heart rate and prolong QT interval. Observe patients who are receiving concomitant QT prolonging drugs with continuous ECG monitoring overnight in a medical facility when initiating fingolimod therapy12.
Why it happens (mechanism)
Additive QT interval prolongation
Common questions
Can I take Arsenic Trioxide Injection and Fingolimod together?
Increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Arsenic Trioxide Injection and Fingolimod interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Arsenic Trioxide Injection or Fingolimod need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: Tascenso ODT(TM) orally disintegrating tablets, fingolimod orally disintegrating tablets. Handa Neuroscience, LLC (per FDA), San Jose, CA, 2021.
- Product Information: GILENYA(R) oral capsules, fingolimod oral capsules. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2018. DailyMed
Keep reading about Arsenic Trioxide Injection
Keep reading about Fingolimod
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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