Drug Interaction Report

Asenapine Transdermal Patch and Enoxacin: Interaction Details

A pharmacist-reviewed analysis of the Asenapine Transdermal Patch and Enoxacin interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Asenapine Transdermal Patch

Secuado Secuado®
+

Enoxacin

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Jul 11, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 377 documented Asenapine Transdermal Patch interactions, 276 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
probable
Severity
Major

What happens

Increased asenapine exposure

Interaction Deep Dive

Concomitant use of asenapine (a CYP1A2 substrate) with a strong CYP1A2 inhibitor may result in increased exposure to asenapine. Reduce asenapine dosage based on clinical response, if necessary1.423.

Why it happens (mechanism)

Inhibition of CYP1A2-mediated metabolism of asenapine

Literature reports

1 report — tap to read

a) Coadministration of fluvoxaMINE (strong CYP1A2 inhibitor) and asenapine increased the Cmax and AUC of asenapine by approximately 1.1 fold and 1.2 fold, respectively 2. Marginal increase of asenapine exposure was observed when asenapine is used with fluvoxaMINE at 25 mg administered twice daily 123.

Common questions

Can I take Asenapine Transdermal Patch and Enoxacin together?

Increased asenapine exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Asenapine Transdermal Patch and Enoxacin interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Asenapine Transdermal Patch or Enoxacin need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (4)

  1. Product Information: SAPHRIS(R) oral sublingual tablets, asenapine oral sublingual tablets. Allergan USA, Inc. (per DailyMed), Madison, NJ, 2021. DailyMed
  2. Product Information: SECUADO® transdermal system, asenapine transdermal system. Noven Therapeutics LLC (per DailyMed), Miami, FL, 2023. DailyMed
  3. Product Information: Asenapine oral sublingual tablets, asenapine oral sublingual tablets. Alembic Pharmaceuticals Ltd (per DailyMed), Bedminster, NJ, 2025. DailyMed
  4. Product Information: Asenapine oral sublingual tablets, asenapine oral sublingual tablets. Breckenridge Pharmaceutical Inc.(per DailyMed), Berkeley Heights, NJ, 2021. DailyMed
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Asenapine Transdermal Patch

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All Asenapine Transdermal Patch interactions (377) Asenapine Transdermal Patch drug information
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Enoxacin

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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Enoxacin + Activated Charcoal Apple Grapefruit Sweet Orange Alfalfa Angelica Archangelica Arrach Bacillus Coagulans + 100 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.