Asenapine Transdermal Patch

377 interactions 1 explained in plain English 412 cited references

Also sold as: Secuado Secuado®

About Asenapine Transdermal Patch

Asenapine transdermal patches are used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Asenapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain… Read the full Asenapine Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Metoclopramide Pimozide Piperaquine Bepridil

15 Contraindicated 276 Major 86 Moderate

All (377) Contraindicated (15) Major (276) Moderate (86)

Contraindicated

Asenapine Transdermal Patch Bepridil An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Bromopride Increased risk of extrapyramidal reactions Details Asenapine Transdermal Patch Cisapride Propulsid® Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Dronedarone Multaq Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Isocarboxazid Marplan An increased risk of CNS depression Details Asenapine Transdermal Patch Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Asenapine Transdermal Patch Mesoridazine Increased risk of CNS depression and an increased risk of QT interval prolongation Details Asenapine Transdermal Patch Metoclopramide An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Asenapine Transdermal Patch Pimozide Increased risk of CNS depression and an increased risk of QT interval prolongation Details Asenapine Transdermal Patch Piperaquine An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Saquinavir An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sparfloxacin An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Terfenadine An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Thioridazine An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Ziprasidone Geodon An increased risk of QT interval prolongation and an increased risk of CNS depression Details

Major

Asenapine Transdermal Patch Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Asenapine Transdermal Patch Alfentanil Increased risk of respiratory or CNS depression and hypotension Details Asenapine Transdermal Patch Alfuzosin UroXatral An increased risk of QT interval prolongation and an increased risk of hypotension Details Asenapine Transdermal Patch Alprazolam Xanax Increased risk of CNS depression Details Asenapine Transdermal Patch Amiodarone Nexterone Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Asenapine Transdermal Patch Amitriptyline Elavil Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Amoxapine An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Anagrelide Agrylin Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Apomorphine Apokyn An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Aripiprazole Abilify An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Artemether An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Astemizole Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Atazanavir Reyataz An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Azithromycin AzaSite Increased risk of QT interval prolongation and torsade de pointes Details Asenapine Transdermal Patch Bedaquiline Sirturo Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Benzhydrocodone Increased risk of respiratory and CNS depression Details Asenapine Transdermal Patch Bromazepam Increased risk of respiratory or cardiovascular depression Details Asenapine Transdermal Patch Buprenorphine Belbuca An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Asenapine Transdermal Patch Butalbital An increased risk of CNS depression Details Asenapine Transdermal Patch Butorphanol Butorphic Increased risk of respiratory and CNS depression Details Asenapine Transdermal Patch Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Asenapine Transdermal Patch Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.