Asenapine Transdermal Patch and Telavancin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Asenapine Transdermal Patch
Telavancin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of QT interval prolongation
Interaction Deep Dive
Avoid coadministration of asenapine with drugs that prolong the QT interval due to the potential for additive effects on the QT interval123.
Why it happens (mechanism)
Additive QT interval prolongation
Literature reports
1 report — tap to read
a) In an electrocardiographic study of 151 clinically stable patients, administration of asenapine in doses of 5 mg, 10 mg, 15 mg, and 20 mg twice daily resulted in 2 to 5 milliseconds increases in QTc interval compared with placebo. QTc interval increases of 500 milliseconds or more and QTc increases of 60 milliseconds or more from baseline measurements were not experienced by any patient 123.
Common questions
Can I take Asenapine Transdermal Patch and Telavancin together?
Increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Asenapine Transdermal Patch and Telavancin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Asenapine Transdermal Patch or Telavancin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: SAPHRIS(R) oral sublingual tablets, asenapine oral sublingual tablets. Allergan USA, Inc. (per DailyMed), Madison, NJ, 2021. DailyMed
- Product Information: SECUADO® transdermal system, asenapine transdermal system. Noven Therapeutics LLC (per DailyMed), Miami, FL, 2023. DailyMed
- Product Information: Asenapine oral sublingual tablets, asenapine oral sublingual tablets. Alembic Pharmaceuticals Ltd (per DailyMed), Bedminster, NJ, 2025. DailyMed
Keep reading about Asenapine Transdermal Patch
Keep reading about Telavancin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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