Drug Interaction Report

Asenapine Transdermal Patch and Propranolol: Interaction Details

A pharmacist-reviewed analysis of the Asenapine Transdermal Patch and Propranolol interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Asenapine Transdermal Patch

Secuado Secuado®
+

Propranolol

Hemangeol Inderal InnoPran
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Jul 11, 2026
Editorial policy · Data sources
LinkedIn
Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 377 documented Asenapine Transdermal Patch interactions, 86 are rated moderate — including this one.
Onset
unspecified
Evidence
theoretical
Severity
Moderate

What happens

An increased risk of hypotension

Interaction Deep Dive

Coadministration of asenapine and beta blockers may increase the risk of hypotension. Monitor blood pressure and adjust dosage accordingly123.

Why it happens (mechanism)

Additive hypotensive effects

Common questions

Can I take Asenapine Transdermal Patch and Propranolol together?

An increased risk of hypotension Always confirm with your pharmacist or prescriber before making any change.

How serious is the Asenapine Transdermal Patch and Propranolol interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Asenapine Transdermal Patch or Propranolol need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (3)

  1. Product Information: SAPHRIS(R) oral sublingual tablets, asenapine oral sublingual tablets. Allergan USA, Inc. (per DailyMed), Madison, NJ, 2021. DailyMed
  2. Product Information: SECUADO® transdermal system, asenapine transdermal system. Noven Therapeutics LLC (per DailyMed), Miami, FL, 2023. DailyMed
  3. Product Information: Asenapine oral sublingual tablets, asenapine oral sublingual tablets. Alembic Pharmaceuticals Ltd (per DailyMed), Bedminster, NJ, 2025. DailyMed
Was this write-up helpful?
Asenapine Transdermal Patch

Keep reading about Asenapine Transdermal Patch

All Asenapine Transdermal Patch interactions (377) Asenapine Transdermal Patch drug information
Also serious with: Levoketoconazole Mesoridazine Metoclopramide Pimozide
Propranolol

Keep reading about Propranolol

All Propranolol interactions (76) Propranolol drug information
Also serious with: Mefloquine Lacosamide Injection Capmatinib Indacaterol Oral Inhalation
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Propranolol + Activated Charcoal American Hellebore American Mistletoe Indian Snakeroot Tyramine 1,3-dmaa Acacia Rigidula Active Hexose Correlated Compound (ahcc) + 228 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.