Propranolol
76 interactions 5 explained in plain English
Also sold as:
Hemangeol
Inderal
InnoPran
Read the full Propranolol drug information page
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Aug 8, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Abametapir
Olodaterol Oral Inhalation
Capmatinib
Mefloquine
Dihydroergotamine Injection
Lacosamide Injection
Major
Propranolol Abametapir Explained Increased exposure of CYP1A2 substrates Details Propranolol Albuterol Oral Inhalation Accuneb® Explained Reduced efficacy of albuterol Details Propranolol Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Propranolol Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Propranolol Dihydroergotamine Injection DHE-45® Injection Increased risk of coronary artery vasospasm Details Propranolol Dihydroergotamine Nasal Spray Migranal Increased risk of coronary artery vasospasm Details Propranolol Indacaterol Oral Inhalation Arcapta® Decreased efficacy of indacaterol Details Propranolol Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Propranolol Mefloquine Lariam® An increased risk of ECG abnormalities and cardiac arrest Details Propranolol Methylergonovine Methergine An increased risk of enhanced vasoconstrictive Details Propranolol Olodaterol Oral Inhalation Striverdi Reduced olodaterol exposure and reduced beta-adrenergic blockers exposure DetailsModerate
Propranolol Omeprazole Gastrobim Explained Increased propranolol exposure Details Propranolol Sertraline Explained Increased propranolol exposure Details Propranolol Acarbose Prandase® Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Propranolol Aspirin Acuprin® Reduced antihypertensive effect Details Propranolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Propranolol Abiraterone Abirtega Increased propranolol exposure Details Propranolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Propranolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Propranolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Cholestyramine Resin Locholest® Decreased propranolol exposure Details Propranolol Colestipol Colestid Decreased propranolol effectiveness Details Propranolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Propranolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Propranolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Propranolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Propranolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Propranolol Dobutamine Reduced sensitivity to DOBUTamine stress echocardiography Details Propranolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Propranolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Esomeprazole Nexium Increased propranolol exposure Details Propranolol Esomeprazole Injection Nexium Increased propranolol exposure Details Propranolol Etodolac Lodine Reduced antihypertensive effect Details Propranolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Fenoprofen Fenopron Reduced antihypertensive effect DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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