Aspirin Rectal

385 interactions 2 explained in plain English 1,426 cited references

Also sold as: Aspirin

About Aspirin Rectal

Aspirin rectal is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood c… Read the full Aspirin Rectal drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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6 Contraindicated 268 Major 107 Moderate 4 Minor

All (385) Contraindicated (6) Major (268) Moderate (107) Minor (4)

Moderate

Aspirin Rectal Glyburide DiaBeta® Increased risk of hypoglycemia Details Aspirin Rectal Guggul Increased risk of bleeding Details Aspirin Rectal Hawthorn Increased risk of bleeding Details Aspirin Rectal Ibritumomab Tiuxetan An increased risk of bleeding and hemorrhage Details Aspirin Rectal Icosapent Ethyl Vascepa An increased risk of bleeding Details Aspirin Rectal Iloprost Aurlumyn Increased risk of bleeding Details Aspirin Rectal Imidapril Decreased imidapril effectiveness Details Aspirin Rectal Insulin Afrezza Increased risk of hypoglycemia Details Aspirin Rectal Insulin Aspart, Recombinant Fiasp Increased risk of hypoglycemia Details Aspirin Rectal Insulin Bovine Increased risk of hypoglycemia Details Aspirin Rectal Insulin Degludec Tresiba Increased risk of hypoglycemia Details Aspirin Rectal Insulin Detemir Levemir Increased risk of hypoglycemia Details Aspirin Rectal Insulin Glargine, Recombinant Basaglar Increased risk of hypoglycemia Details Aspirin Rectal Insulin Glulisine Apidra Increased risk of hypoglycemia Details Aspirin Rectal Insulin Lispro, Recombinant Admelog Increased risk of hypoglycemia Details Aspirin Rectal Kava Increased risk of bleeding Details Aspirin Rectal Labetalol Normodyne® Reduced antihypertensive effect Details Aspirin Rectal Lecanemab-Irmb An increased risk of amyloid related imaging abnormalities (ARIA), or intracerebral hemorrhage Details Aspirin Rectal Lesinurad Decreased efficacy of lesinurad Details Aspirin Rectal Levobunolol Betagan Reduced antihypertensive effect Details Aspirin Rectal Levofloxacin Levaquin An increased risk of seizures Details Aspirin Rectal Licorice Increased risk of bleeding Details Aspirin Rectal L-Methylfolate Decreased l-methylfolate efficacy Details Aspirin Rectal Magaldrate Decreased salicylate effectiveness Details Aspirin Rectal Magnesium Carbonate Decreased salicylate effectiveness Details Aspirin Rectal Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Decreased salicylate effectiveness Details Aspirin Rectal Magnesium Oxide Mag-Ox 400 Decreased salicylate effectiveness Details Aspirin Rectal Magnesium Trisilicate Decreased salicylate effectiveness Details Aspirin Rectal Ma Huang Increased risk of developing gastric mucosal lesions Details Aspirin Rectal Meadowsweet Increased risk of bleeding Details Aspirin Rectal Metformin Fortamet® Increased risk of hypoglycemia Details Aspirin Rectal Metipranolol Reduced antihypertensive effect Details Aspirin Rectal Metoprolol Kapspargo Reduced antihypertensive effect Details Aspirin Rectal Motherwort Increased risk of bleeding Details Aspirin Rectal Nadolol Corgard Reduced antihypertensive effect Details Aspirin Rectal Nateglinide Starlix® Increased risk of hypoglycemia Details Aspirin Rectal Nebivolol Bystolic Reduced antihypertensive effect Details Aspirin Rectal Nitroglycerin Gonitro An increase in nitroglycerin concentrations and additive platelet function depression Details Aspirin Rectal Norfloxacin An increased risk of seizures Details Aspirin Rectal Ofloxacin Floxin® An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.