Aspirin Rectal

385 interactions 2 explained in plain English 1,426 cited references
Also sold as: Aspirin
About Aspirin Rectal

Aspirin rectal is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood c… Read the full Aspirin Rectal drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abrocitinib Influenza Virus Vaccine, Live Ketorolac Probenecid Dichlorphenamide Defibrotide
6 Contraindicated 268 Major 107 Moderate 4 Minor
All (385) Contraindicated (6) Major (268) Moderate (107) Minor (4)

Contraindicated

Aspirin Rectal Abrocitinib Cibinqo Increased risk of bleeding Details Aspirin Rectal Defibrotide Increased risk of bleeding Details Aspirin Rectal Dichlorphenamide Increased salicylate exposure , increased dichlorphenamide exposure and its toxicity Details Aspirin Rectal Influenza Virus Vaccine, Live An increased risk of Reye's syndrome in children and adolescents 2 to 17 years of age Details Aspirin Rectal Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding, and/or perforation) and possible increase in... Details Aspirin Rectal Probenecid Salicylates antagonize the uricosuric effects of probenecid Details

Major

Aspirin Rectal Aceclofenac An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Aspirin Rectal Acemetacin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Aspirin Rectal Acenocoumarol Increased risk of bleeding Details Aspirin Rectal Acetazolamide Diamox® Sequels® Salicylate toxicity (vomiting, tachycardia, hyperpnea, mental confusion) or acetaZOLAMIDE toxicity (fatigue, lethargy, somnolence,... Details Aspirin Rectal Alclometasone An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Aspirin Rectal Aldosterone An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Aspirin Rectal Alipogene Tiparvovec An increased risk of bleeding Details Aspirin Rectal Alteplase, Recombinant Activase An increased risk of bleeding Details Aspirin Rectal Amcinonide An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Aspirin Rectal Amikacin Increased aspirin exposure and an increased risk of nephrotoxicity Details Aspirin Rectal Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Aspirin Rectal Amineptine An increased risk of bleeding Details Aspirin Rectal Amitriptyline Elavil An increased risk of bleeding Details Aspirin Rectal Amitriptylinoxide An increased risk of bleeding Details Aspirin Rectal Amoxapine An increased risk of bleeding Details Aspirin Rectal Amphotericin B Increased aspirin exposure and an increased risk of nephrotoxicity Details Aspirin Rectal Amtolmetin Guacil An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Aspirin Rectal Anagrelide Agrylin An increased risk of bleeding Details Aspirin Rectal Anisindione An increased risk of bleeding Details Aspirin Rectal Apixaban Eliquis Explained Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Aspirin Rectal Ardeparin Increased risk of bleeding Details Aspirin Rectal Argatroban Increased risk of bleeding Details Aspirin Rectal Bacitracin Increased aspirin exposure and an increased risk of nephrotoxicity Details Aspirin Rectal Beclomethasone An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Aspirin Rectal Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Aspirin Rectal Bemiparin Increased risk of bleeding Details Aspirin Rectal Benazepril Lotensin Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Aspirin Rectal Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Aspirin Rectal Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Aspirin Rectal Betamethasone Betavet An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Aspirin Rectal Betrixaban Bevyxxa® Increased risk of bleeding Details Aspirin Rectal Bivalirudin Angiomax Increased risk of bleeding Details Aspirin Rectal Brinzolamide Increased carbonic anhydrase inhibitors exposure and its toxicity Details Aspirin Rectal Bromfenac Bromsite An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.