Aspirin Rectal and Tirofiban: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Aspirin Rectal
Tirofiban
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of bleeding
Interaction Deep Dive
Tirofiban was studied in combination with heparin and aspirin in three large clinical trials involving 3948 patients. The incidence of bleeding was increased with tirofiban and heparin coadministration as compared to heparin alone. Patients also received aspirin unless it was contraindicated2. Caution is recommended with the concomitant use of aspirin, an antiplatelet agent 1, and tirofiban, a platelet aggregation inhibitor, due to the increased risk of bleeding 2. If coadministration cannot be avoided, monitoring of signs and symptoms of active bleeding may be warranted.
Why it happens (mechanism)
Additive antiplatelet effects
Literature reports
1 report — tap to read
a) In the PRISM-PLUS (Platelet Receptor Inhibition for Ischemic Syndrome Management - Patients Limited by Unable Signs and Symptoms) study, 1.4% of 773 patients who received heparin and tirofiban experienced a major bleeding episode, as compared to 0.8% of 797 patients who received only heparin. Similarly, in the RESTORE (Randomized Efficacy Study of Tirofiban for Outcomes and Restenosis) study, 2.2% of 1071 patients on tirofiban and heparin had a major bleeding episode, compared to 1.6% of 1070 patients on heparin alone. A major bleeding episode was defined as a hemoglobin drop of greater than 50 g/L with or without an identified site, intracranial hemorrhage, or cardiac tamponade. All patients were also receiving aspirin unless contraindicated. Minor bleeding episodes, defined as a hemoglobin drop of greater than 30 g/L with bleeding from a known site, spontaneous gross hematuria, hematemesis, or hemoptysis, occurred in 10.5% of patients receiving tirofiban and heparin in the PRISM-PLUS study, and only 8% of patients on heparin monotherapy. In the RESTORE study, 12% of tirofiban/heparin recipients had a minor bleed in contrast to 6.3% on heparin alone 2.
Common questions
Can I take Aspirin Rectal and Tirofiban together?
An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Aspirin Rectal and Tirofiban interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Aspirin Rectal or Tirofiban need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: AGGRENOX(R) oral extended release capsules, aspirin dipyridamole oral extended release capsules. Boehringer Ingelheim Pharmaceuticals, Inc. (per FDA), Ridgefield, CT, 2012. DailyMed
- Product Information: AGGRASTAT(R) intravenous injection solution, tirofiban HCl intravenous injection solution. Medicure Pharma, Inc. (per DailyMed), Somerset, NJ, 2012. DailyMed
Keep reading about Aspirin Rectal
Keep reading about Tirofiban
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