Aspirin Rectal and Feverfew: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Aspirin Rectal
Feverfew
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects)
Interaction Deep Dive
Theoretically, concomitant use of feverfew with an NSAID may predispose the patient to more adverse effects (eg, gastropathy, increased risk of bleeding, and nephropathy). There is insufficient benefit to offset perceived risk in combining these 2 agents. Feverfew inhibits prostaglandin synthesis but does not inhibit the cyclooxygenase enzyme234. Thromboxane synthesis is also suppressed by feverfew 1. It is unlikely that further suppression with an NSAID will lead to any clinical benefit.
Why it happens (mechanism)
Additive prostaglandin and thromboxane inhibition
Common questions
Can I take Aspirin Rectal and Feverfew together?
Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Aspirin Rectal and Feverfew interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Aspirin Rectal or Feverfew need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (4)
- Abebe W: Herbal medication: Potential for adverse interactions with analgesic drugs. J Clin Pharm Ther 2002; 27(6):391-401. PubMed
- Sumner H, Salan U, Knight DW, et al: Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Biochem Pharmacol 1992; 43:2313-2320. DOI
- Makheja A & Bailey J: A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prost Leuk Med 1982; 8:653-660.
- Collier HOJ, Butt NM, McDonald-Gibson WJ, et al: Extract of feverfew inhibits prostaglandin biosynthesis. Lancet 1980; 1:922-923. DOI
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