Astemizole

63 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Glasdegib Dasatinib Encorafenib Hydroxychloroquine Oxaliplatin Injection
1 Contraindicated 62 Major
All (63) Contraindicated (1) Major (62)

Major

Astemizole Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate Details Astemizole Lefamulin Xenleta Increased risk of QT interval prolongation Details Astemizole Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Astemizole Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Astemizole Levofloxacin Levaquin Increased risk of QT interval prolongation Details Astemizole Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Astemizole Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Astemizole Mefloquine Lariam® Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Astemizole Metronidazole Flagyl An increased risk of QT interval prolongation Details Astemizole Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Astemizole Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Astemizole Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Astemizole Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Astemizole Moxifloxacin Avelox Increased risk of QT interval prolongation Details Astemizole Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Astemizole Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Astemizole Octreotide Bynfezia An increased risk of QT interval prolongation Details Astemizole Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Astemizole Ofloxacin Floxin® An increased risk of QT interval prolongation Details Astemizole Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Astemizole Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Astemizole Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Astemizole Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.