Astemizole

63 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Glasdegib Dasatinib Encorafenib Hydroxychloroquine Oxaliplatin Injection
1 Contraindicated 62 Major
All (63) Contraindicated (1) Major (62)

Contraindicated

Astemizole Ketoconazole Topical Extina® Foam Increased astemizole exposure and an increased risk of QT interval prolongation Details

Major

Astemizole Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Sertraline Explained Increased astemizole exposure and an increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arre... Details Astemizole Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Astemizole Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Astemizole Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Astemizole Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Astemizole Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Astemizole Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Astemizole Azithromycin AzaSite An increased risk of QT interval prolongation Details Astemizole Alfuzosin UroXatral An increased risk of QT interval prolongation Details Astemizole Anagrelide Agrylin Increased risk of QT interval prolongation Details Astemizole Bedaquiline Sirturo Increased risk of QT interval prolongation Details Astemizole Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Dasatinib Phyrago An increased risk of QT interval prolongation Details Astemizole Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Astemizole Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Astemizole Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Dofetilide Tikosyn Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Astemizole Dolasetron Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Dolasetron Injection Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Enasidenib Idhifa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Astemizole Encorafenib Braftovi Increased risk of QT interval prolongation Details Astemizole Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Astemizole Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Fostemsavir Rukobia Increased risk of torsade de pointes Details Astemizole Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Astemizole Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Glasdegib Daurismo Increased risk of QT interval prolongation Details Astemizole Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Astemizole Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Astemizole Granisetron Injection Granisol An increased risk of QT interval prolongation Details Astemizole Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Astemizole Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Astemizole Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Astemizole Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Astemizole Ivabradine Corlanor Increased risk of QT prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.