Atomoxetine

13 interactions 3 explained in plain English
Also sold as: Atoncy Strattera Strattera®
About Atomoxetine

Atomoxetine is a selective norepinephrine reuptake inhibitor used to improve attention and reduce impulsiveness and hyperactivity in ADHD. Read the full Atomoxetine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Sertraline Albuterol Oral Inhalation Azathioprine Abiraterone Dacomitinib
1 Contraindicated 9 Major 3 Moderate
All (13) Contraindicated (1) Major (9) Moderate (3)

Contraindicated

Atomoxetine Linezolid Injection Zyvox An increased risk of atomoxetine-related serious or fatal adverse reactions (including hyperthermia, rigidity, myoclonus, autonomi... Details

Major

Atomoxetine Sertraline Explained Increased CYP2D6 substrate exposure Details Atomoxetine Albuterol Oral Inhalation Accuneb® Explained Increased albuterol exposure and an increase in heart rate and blood pressure Details Atomoxetine Azathioprine Azasan An increased risk of hepatotoxicity Details Atomoxetine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Atomoxetine Dacomitinib Vizimpro Increased atomoxetine exposure and an increased risk of atomoxetine-related adverse reactions Details Atomoxetine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Atomoxetine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Atomoxetine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Atomoxetine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details

Moderate

Atomoxetine Amitriptyline Elavil Explained An increase in atomoxetine steady-state plasma concentrations Details Atomoxetine Dobutamine An increased risk of increased blood pressure Details Atomoxetine Dopamine An increased risk of increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.