Atropine Ophthalmic and Cisapride: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Atropine Ophthalmic
Cisapride
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Loss of cisapride efficacy
Interaction Deep Dive
Concurrent use of an anticholinergic agent with cisapride is likely to counteract gastrointestinal motility normally induced by cisapride21.
Why it happens (mechanism)
Pharmacodynamic antagonism
Literature reports
1 report — tap to read
a) The effects of cisapride on peristaltic contractions were completely blocked by atropine, irrespective of whether atropine was administered before or after cisapride. Lower esophageal sphincter pressure response to cisapride varied according to the sequence of drug administration. When cisapride followed atropine cisapride exerted no effect. When this sequence was reversed, no significant atropine induced inhibition on cisapride-stimulated lower esophageal sphincter pressure occurred 1.
Common questions
Can I take Atropine Ophthalmic and Cisapride together?
Loss of cisapride efficacy Always confirm with your pharmacist or prescriber before making any change.
How serious is the Atropine Ophthalmic and Cisapride interaction?
It is rated minor. Usually limited clinical impact.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Atropine Ophthalmic or Cisapride need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
Keep reading about Atropine Ophthalmic
Keep reading about Cisapride
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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