Azelastine Ophthalmic

Name: Azelastine Ophthalmic Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions 97 cited references

Also sold as: Optivar®

About Azelastine Ophthalmic

Ophthalmic azelastine is used to relieve the itching of allergic pink eye. Azelastine is in a class of medications called antihistamines. It works by blocking histamine, a substance in the body that causes allergic symptoms. Read the full Azelastine Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amifampridine Bupropion Clomipramine Donepezil Hydroxychloroquine Pitolisant

7 Major 1 Moderate

All (8) Major (7) Moderate (1)

Major

Azelastine Ophthalmic Amifampridine Increased risk of seizures Details Azelastine Ophthalmic Bupropion Aplenzin Increased risk of seizures Details Azelastine Ophthalmic Clomipramine Anafranil Increased risk of seizures Details Azelastine Ophthalmic Donepezil Adlarity Reduced seizure threshold Details Azelastine Ophthalmic Hydroxychloroquine Plaquenil An increased risk of seizures Details Azelastine Ophthalmic Pitolisant Wakix Reduced efficacy of pitolisant Details Azelastine Ophthalmic Tramadol ConZip An increased risk of seizure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.