Azithromycin

299 interactions 4 explained in plain English 730 cited references

Also sold as: AzaSite Zithromax Zithromax® Zithromax® Single Dose Packets Zithromax® Tri-Paks® Zithromax® Z-Paks® Zmax®

About Azithromycin

Azithromycin is a macrolide antibiotic used to treat bacterial infections of the respiratory tract, skin, throat, ears, and reproductive organs. Read the full Azithromycin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Levoketoconazole Saquinavir Mesoridazine Colchicine Pimozide

13 Contraindicated 264 Major 11 Moderate 11 Minor

All (299) Contraindicated (13) Major (264) Moderate (11) Minor (11)

Contraindicated

Azithromycin Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Azithromycin Bepridil An increased risk of QT interval prolongation Details Azithromycin Cisapride Propulsid® Increased risk of QT interval prolongation Details Azithromycin Dronedarone Multaq Increased risk of QT interval prolongation Details Azithromycin Levoketoconazole Recorlev An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Azithromycin Mesoridazine An increased risk of QT interval prolongation Details Azithromycin Pimozide Increased pimozide exposure and an increased risk of QT interval prolongation Details Azithromycin Piperaquine An increased risk of QT interval prolongation Details Azithromycin Saquinavir An increased risk of QT interval prolongation Details Azithromycin Sparfloxacin An increased risk of QT interval prolongation Details Azithromycin Terfenadine An increased risk of QT interval prolongation Details Azithromycin Thioridazine An increased risk of QT interval prolongation Details Azithromycin Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Azithromycin Amitriptyline Elavil An increased risk of QT interval prolongation Details Azithromycin Sertraline An increased risk of QT interval prolongation Details Azithromycin Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Azithromycin Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Azithromycin Simvastatin Flolipid Explained An increased risk of rhabdomyolysis Details Azithromycin Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Azithromycin Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Azithromycin Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Azithromycin Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Azithromycin Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation and torsade de pointes Details Azithromycin Azathioprine Azasan An increased risk of hepatotoxicity Details Azithromycin Acecainide An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Azithromycin Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Azithromycin Alfentanil Increased ALfentanil exposure and an increased risk of respiratory depression Details Azithromycin Alfuzosin UroXatral An increased risk of QT interval prolongation Details Azithromycin Amiodarone Nexterone An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Azithromycin Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Azithromycin Amoxapine An increased risk of QT interval prolongation Details Azithromycin Anagrelide Agrylin Increased risk of QT interval prolongation Details Azithromycin Apomorphine Apokyn An increased risk of QT interval prolongation Details Azithromycin Aripiprazole Abilify An increased risk of QT interval prolongation Details Azithromycin Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Azithromycin Artemether Increased artemether/lumefantrine exposure and an increased risk of QT prolongation Details Azithromycin Asenapine Saphris Increased risk of QT interval prolongation and torsade de pointes Details Azithromycin Astemizole An increased risk of QT interval prolongation Details Azithromycin Atazanavir Reyataz An increased risk of QT interval prolongation Details Azithromycin Bedaquiline Sirturo An increased risk of QT interval prolongation and torsade de pointes Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.