Drug Interaction Report

Becaplermin Topical and Feverfew: Interaction Details

Name: Becaplermin Topical and Feverfew Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Becaplermin Topical and Feverfew interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Becaplermin Topical

Regranex Regranex®

Feverfew

No brand names on record

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Moderate

Can be significant — usually manageable with monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 25 documented Becaplermin Topical interactions, 23 are rated moderate — including this one.

Onset

delayed

Evidence

theoretical

Severity

Moderate

What happens

Increased risk of bleeding

Interaction Deep Dive

Theoretically, antiplatelet activity of feverfew may lead to bleeding complications when combined with antiplatelet agents¹. In vitro data demonstrates that feverfew, and in particular parthenolide, inhibits platelet aggregation ²³.

Why it happens (mechanism)

Feverfew may inhibit platelet aggregation through reduced thromboxane A2 production, leading to additive anticoagulant effect

Common questions

Can I take Becaplermin Topical and Feverfew together?

Increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.

How serious is the Becaplermin Topical and Feverfew interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Becaplermin Topical or Feverfew need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there anything you'd monitor while I'm on both?

References (3)

Norred CL & Brinker F: Potential coagulation effects of preoperative complementary and alternative medicines. Alt Ther 2001; 7(6):58-67.
Makheja AN & Bailey JM: A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostagl Leukotr Med 1982; 8:653-60.
Makheja AN & Bailey JM: The active principle in feverfew. Lancet 1981; 2:1054. PubMed

Was this write-up helpful?

Becaplermin Topical

Keep reading about Becaplermin Topical

All Becaplermin Topical interactions (25) Becaplermin Topical drug information

Feverfew

Keep reading about Feverfew

All Feverfew interactions (37)

Also serious with: Ketorolac Flurbiprofen Naproxen Ketorolac Ophthalmic

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

A message from HelloPharmacist

About our interaction database: depth, not breadth

HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.