Belladonna

18 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Buprenorphine Fentanyl Transdermal Patch Glucagon Injection Glucagon Injection / Solution Glucagon Nasal Powder
10 Major 1 Moderate 7 Minor
All (18) Major (10) Moderate (1) Minor (7)

Major

Belladonna Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Belladonna Buprenorphine Belbuca Explained An increased risk of paralytic ileus Details Belladonna Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Belladonna Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Belladonna Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Belladonna Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Belladonna Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Belladonna Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Belladonna Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Belladonna Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus Details

Moderate

Belladonna Amitriptyline Elavil Explained Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details

Minor

Belladonna Atropine Ophthalmic Atropine Care 1% Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Bethanechol Duvoid® Reduced effectiveness of bethanechol Details Belladonna Cyclopentolate Ophthalmic Akpentolate® Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Diphenhydramine Injection Banophen Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Diphenhydramine Topical Afterbite with Antihistamine Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Ipratropium Nasal Spray Atrovent Nasal Spray® Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Ipratropium Oral Inhalation Atrovent® HFA Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.