Belladonna Alkaloids

9 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Hydroxychloroquine
1 Major 1 Moderate 7 Minor
All (9) Major (1) Moderate (1) Minor (7)

Major

Belladonna Alkaloids Hydroxychloroquine Plaquenil An increased risk of seizures Details

Moderate

Belladonna Alkaloids Amitriptyline Elavil Explained Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details

Minor

Belladonna Alkaloids Atropine Ophthalmic Atropine Care 1% Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Alkaloids Bethanechol Duvoid® Reduced effectiveness of bethanechol Details Belladonna Alkaloids Cyclopentolate Ophthalmic Akpentolate® Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Alkaloids Diphenhydramine Injection Banophen Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Alkaloids Diphenhydramine Topical Afterbite with Antihistamine Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Alkaloids Ipratropium Nasal Spray Atrovent Nasal Spray® Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details Belladonna Alkaloids Ipratropium Oral Inhalation Atrovent® HFA Excessive anticholinergic activity (severe dry mouth, constipation, decreased urination, excessive sedation, blurred vision) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.