Besifloxacin Ophthalmic

24 interactions 36 cited references
Also sold as: Besivance Besivance®
About Besifloxacin Ophthalmic

Besifloxacin ophthalmic is used to treat bacterial conjunctivitis (pinkeye; infection of the membrane that covers the outside of the eyeballs and the inside of the eyelids). Besifloxacin is in a class of medications called fluoroquinolones. It works by killing the bacteria that cause infection. Read the full Besifloxacin Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Anagrelide Betamethasone Budesonide Bupropion Cholera Vaccine, Live Clomipramine
21 Major 3 Moderate
All (24) Major (21) Moderate (3)

Major

Besifloxacin Ophthalmic Anagrelide Agrylin Increased anagrelide exposure Details Besifloxacin Ophthalmic Betamethasone Betavet An increased risk of tendon rupture Details Besifloxacin Ophthalmic Budesonide Entocort An increased risk of tendon rupture Details Besifloxacin Ophthalmic Bupropion Aplenzin Increased risk of seizures Details Besifloxacin Ophthalmic Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Besifloxacin Ophthalmic Clomipramine Anafranil Increased risk of seizures Details Besifloxacin Ophthalmic Corticotropin An increased risk of tendon rupture Details Besifloxacin Ophthalmic Cortisone An increased risk of tendon rupture Details Besifloxacin Ophthalmic Cosyntropin An increased risk of tendon rupture Details Besifloxacin Ophthalmic Deflazacort Emflaza An increased risk of tendon rupture Details Besifloxacin Ophthalmic Dexamethasone An increased risk of tendon rupture Details Besifloxacin Ophthalmic Fludrocortisone An increased risk of tendon rupture Details Besifloxacin Ophthalmic Fluocortolone An increased risk of tendon rupture Details Besifloxacin Ophthalmic Hydrocortisone Ala-Cort An increased risk of tendon rupture Details Besifloxacin Ophthalmic Hydroxychloroquine Plaquenil An increased risk of seizures Details Besifloxacin Ophthalmic Methylprednisolone Depo-Medrol An increased risk of tendon rupture Details Besifloxacin Ophthalmic Prednisolone Flo-Pred® An increased risk of tendon rupture Details Besifloxacin Ophthalmic Prednisone Deltasone An increased risk of tendon rupture Details Besifloxacin Ophthalmic Rasagiline Azilect Increased rasagiline exposure Details Besifloxacin Ophthalmic Tramadol ConZip An increased risk of seizure Details Besifloxacin Ophthalmic Triamcinolone Aller-Cort An increased risk of tendon rupture Details

Moderate

Besifloxacin Ophthalmic Aminolevulinic Acid Increased risk of phototoxic skin reaction (ie, severe sunburn) Details Besifloxacin Ophthalmic Lanthanum Carbonate Fosrenol Reduced bioavailability of quinolone antibiotics Details Besifloxacin Ophthalmic Strontium Ranelate Decreased bioavailability and exposure of strontium ranelate Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.