Bexarotene Topical and Ranolazine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Ranolazine
Bexarotene Topical
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced ranolazine exposure
Interaction Deep Dive
Coadministration of ranolazine (CYP3A4 substrate) and a CYP3A4 inducer is contraindicated as it may reduce ranolazine exposure. In a drug interaction study, coadministration of rifAMPin 600 mg once daily and ranolazine (1000 mg twice daily) resulted in reduced ranolazine exposure by approximately 95%1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of ranolazine
Literature reports
1 report — tap to read
a) In a drug interaction study, coadministration of rifAMPin (CYP3A4 inducer) 600 mg once daily and ranolazine (1000 mg twice daily) resulted in reduced ranolazine exposure by approximately 95% 1.
Common questions
Can I take Bexarotene Topical and Ranolazine together?
Reduced ranolazine exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Bexarotene Topical and Ranolazine interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Bexarotene Topical or Ranolazine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: RANOLAZINE oral extended-release tablets, ranolazine oral extended-release tablets. Viona Pharmaceuticals Inc. (per Dailymed), Cranford, NJ, 2023. DailyMed
Keep reading about Ranolazine
Keep reading about Bexarotene Topical
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