Bexarotene Topical

75 interactions 92 cited references

Also sold as: Targretin Targretin® Topical Gel

About Bexarotene Topical

Topical bexarotene is used to treat cutaneous T-cell lymphoma (CTCL, a type of skin cancer) that could not be treated with other medications. Bexarotene is in a class of medications called retinoids. It works by stopping the growth of cancer cells. Read the full Bexarotene Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Ranolazine Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Typhoid Vaccine

10 Contraindicated 54 Major 11 Moderate

All (75) Contraindicated (10) Major (54) Moderate (11)

Contraindicated

Bexarotene Topical Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Ranolazine Aspruzyo Reduced ranolazine exposure Details Bexarotene Topical Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Bexarotene Topical Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Bexarotene Topical Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Bexarotene Topical Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Alfentanil Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Bexarotene Topical Amlodipine Amvaz® Reduced amLODIPine exposure Details Bexarotene Topical Atogepant Qulipta Reduced atogepant exposure Details Bexarotene Topical Azathioprine Azasan An increased risk of hepatotoxicity Details Bexarotene Topical Cariprazine Vraylar Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Bexarotene Topical Chlortetracycline An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Topical Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Bexarotene Topical Demeclocycline Declomycin® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Topical Desogestrel Decreased contraceptive effectiveness Details Bexarotene Topical Dienogest Decreased contraceptive effectiveness Details Bexarotene Topical Doxycycline Acticlate An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Topical Drospirenone Decreased contraceptive effectiveness Details Bexarotene Topical Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Efavirenz Reduced efavirenz exposure with reduced efficacy; reduced bexarotene exposure with reduced efficacy Details Bexarotene Topical Eravacycline Xerava An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Topical Estradiol Delestrogen Decreased contraceptive effectiveness Details Bexarotene Topical Ethinyl Estradiol Decreased contraceptive effectiveness Details Bexarotene Topical Ethynodiol Decreased contraceptive effectiveness Details Bexarotene Topical Etonogestrel Nexplanon Decreased contraceptive effectiveness Details Bexarotene Topical Gemfibrozil Lopid Increased plasma concentrations of bexarotene Details Bexarotene Topical Gestodene Decreased contraceptive effectiveness Details Bexarotene Topical Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bexarotene Topical Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Bexarotene Topical Levonorgestrel After banger Decreased contraceptive effectiveness Details Bexarotene Topical Lumateperone Caplyta Reduced lumateperone exposure Details Bexarotene Topical Lymecycline An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Topical Meclocycline An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Topical Medroxyprogesterone Amen® Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.