Bortezomib

33 interactions 448 cited references
Also sold as: Boruzu Velcade Velcade®
About Bortezomib

Bortezomib is used to treat people with multiple myeloma (a type of cancer of the bone marrow). Bortezomib is also used to treat people with mantle cell lymphoma (a fast-growing cancer that begins in the cells of the immune system). Bortezomib is in a class of medications called antineoplastic agents. It works by killi… Read the full Bortezomib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Bortezomib Azathioprine Azasan An increased risk of hepatotoxicity Details Bortezomib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Bortezomib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Bortezomib Apalutamide Erleada Reduced bortezomib exposure Details Bortezomib Carbamazepine Carbatrol Reduced bortezomib exposure Details Bortezomib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Bortezomib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Bortezomib Enzalutamide Xtandi Reduced bortezomib exposure Details Bortezomib Fosphenytoin Cerebyx Reduced bortezomib exposure Details Bortezomib Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bortezomib Itraconazole Sporanox Increased bortezomib exposure and an increased risk of bortezomib-related adverse effects Details Bortezomib Ketoconazole Extina Increased bortezomib exposure Details Bortezomib Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Bortezomib Lumacaftor Reduced bortezomib exposure Details Bortezomib Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Bortezomib Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Bortezomib Mitotane Lysodren Reduced bortezomib exposure Details Bortezomib Phenytoin Dilantin Reduced bortezomib exposure Details Bortezomib Rifampin Rifadin Reduced bortezomib exposure Details Bortezomib Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Bortezomib St John's Wort Reduced bortezomib exposure Details Bortezomib Ketoconazole Topical Extina® Foam Increased bortezomib exposure Details Bortezomib Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.