Bosentan

Name: Bosentan Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

67 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cyclosporine Ophthalmic Cyclosporine Injection Leniolisib Cabozantinib (Thyroid Cancer) Deflazacort Olutasidenib

2 Contraindicated 53 Major 12 Moderate

All (67) Contraindicated (2) Major (53) Moderate (12)

Major

Bosentan Lumateperone Caplyta Reduced lumateperone exposure Details Bosentan Lurasidone Latuda Reduced lurasidone exposure Details Bosentan Medroxyprogesterone Amen® Reduced medroxyPROGESTERone exposure Details Bosentan Medroxyprogesterone Injection Depo-Provera Reduced medroxyPROGESTERone exposure Details Bosentan Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Bosentan Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Bosentan Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Bosentan Midostaurin Rydapt Increased OATP1B1 substrate exposure Details Bosentan Mitapivat Aqvesme Reduced mitapivat exposure and reduced efficacy of mitapivat Details Bosentan Neratinib Nerlynx Decreased exposure of neratinib and risk of reduced efficacy Details Bosentan Nifedipine Adalat® Reduced NIFEdipine exposure Details Bosentan Olaparib Lynparza Decreased olaparib exposure and efficacy Details Bosentan Olutasidenib Rezlidhia Reduced olutasidenib exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.