Bosentan

Name: Bosentan Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

67 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cyclosporine Ophthalmic Cyclosporine Injection Leniolisib Cabozantinib (Thyroid Cancer) Deflazacort Olutasidenib

2 Contraindicated 53 Major 12 Moderate

All (67) Contraindicated (2) Major (53) Moderate (12)

Moderate

Bosentan Simvastatin Flolipid Explained Reduced plasma concentrations and reduced efficacy of simvastatin Details Bosentan Atorvastatin Atorvaliq Reduced plasma concentrations and reduced efficacy of atorvastatin Details Bosentan Diclofenac Ophthalmic Voltaren® Eye Drops Decreased exposure of diclofenac Details Bosentan Diclofenac Topical (Actinic Keratosis) Pennsaid Decreased exposure of diclofenac Details Bosentan Diclofenac Topical (Arthritis Pain) Pennsaid® Decreased exposure of diclofenac Details Bosentan Diclofenac Transdermal Patch Flector Decreased exposure of diclofenac Details Bosentan Guanfacine Intuniv Decreased guanfacine exposure Details Bosentan Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Bosentan Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details Bosentan Lovastatin Altocor® Reduced plasma concentrations and reduced efficacy of lovastatin Details Bosentan Nimodipine Nimotop Decreased nimodipine serum levels Details Bosentan Ospemifene Osphena Decreased ospemifene exposure and efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.