Brexpiprazole

115 interactions 341 cited references
Also sold as: Rexulti Rexulti®
About Brexpiprazole

Brexpiprazole is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) in adults and children 13 years of age and older. It is also used with an antidepressant to treat depression when symptoms cannot be c… Read the full Brexpiprazole drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Brexpiprazole Sertraline Increased CYP2D6 substrate exposure Details Brexpiprazole Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Brexpiprazole Abiraterone Abirtega Increased brexpiprazole exposure Details Brexpiprazole Abiraterone Acetate Abirtega Increased brexpiprazole exposure Details Brexpiprazole Abiraterone Acetate, Micronized Abirtega Increased brexpiprazole exposure Details Brexpiprazole Adagrasib Krazati Increased brexpiprazole exposure Details Brexpiprazole Amprenavir Increased brexpiprazole exposure Details Brexpiprazole Apalutamide Erleada Reduced brexpiprazole exposure Details Brexpiprazole Aprepitant Aponvie Increased brexpiprazole exposure Details Brexpiprazole Atazanavir Reyataz Increased brexpiprazole exposure Details Brexpiprazole Avacopan Tavneos Increased CYP3A4 substrate exposure Details Brexpiprazole Berotralstat Orladeyo Increased brexpiprazole exposure Details Brexpiprazole Boceprevir Increased brexpiprazole exposure Details Brexpiprazole Bupropion Aplenzin Increased brexpiprazole exposure Details Brexpiprazole Capivasertib Truqap Increased brexpiprazole exposure Details Brexpiprazole Carbamazepine Carbatrol Reduced brexpiprazole exposure Details Brexpiprazole Ceritinib Zykadia Increased brexpiprazole exposure Details Brexpiprazole Cinacalcet Increased brexpiprazole exposure Details Brexpiprazole Ciprofloxacin Increased brexpiprazole exposure and an increased risk of QT interval prolongation and/or torsade de pointes Details Brexpiprazole Citalopram Celexa Increased brexpiprazole exposure Details Brexpiprazole Clarithromycin Biaxin Increased brexpiprazole exposure Details Brexpiprazole Clofazimine Increased brexpiprazole exposure Details Brexpiprazole Cobicistat Tybost Increased brexpiprazole exposure Details Brexpiprazole Conivaptan Vaprisol Increased brexpiprazole exposure Details Brexpiprazole Crizotinib Xalkori Increased brexpiprazole exposure Details Brexpiprazole Dacomitinib Vizimpro Increased brexpiprazole exposure Details Brexpiprazole Darunavir Increased brexpiprazole exposure Details Brexpiprazole Diltiazem Cardizem Increased brexpiprazole exposure Details Brexpiprazole Dronedarone Multaq Increased brexpiprazole exposure Details Brexpiprazole Duloxetine Increased brexpiprazole exposure Details Brexpiprazole Duvelisib Copiktra Increased brexpiprazole exposure Details Brexpiprazole Eliglustat Cerdelga Increased brexpiprazole exposure Details Brexpiprazole Encorafenib Braftovi Reduced brexpiprazole exposure Details Brexpiprazole Enzalutamide Xtandi Reduced brexpiprazole exposure Details Brexpiprazole Erythromycin Erythrocin Stearate Increased brexpiprazole exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.