Brimonidine

24 interactions 3 explained in plain English
Also sold as: Alphagan Lumify Mirvaso
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Olodaterol Oral Inhalation
1 Contraindicated 1 Major 22 Moderate
All (24) Contraindicated (1) Major (1) Moderate (22)

Moderate

Brimonidine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression Details Brimonidine Amitriptyline Elavil Explained Reduced brimonidine hypotensive effects Details Brimonidine Buprenorphine Belbuca Explained An increased risk of CNS depression Details Brimonidine Aripiprazole Injection Abilify An increased risk of CNS depression Details Brimonidine Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Brimonidine Butorphanol Injection Butorphic An increased risk of CNS depression Details Brimonidine Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression Details Brimonidine Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Brimonidine Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Brimonidine Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Brimonidine Diazepam Rectal Diastat An increased risk of CNS depression Details Brimonidine Digoxin Cardoxin® An increased risk of reduced blood pressure Details Brimonidine Diphenhydramine Injection Banophen An increased risk of CNS depression Details Brimonidine Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Brimonidine Esketamine Nasal Spray Spravato An increased risk of CNS depression Details Brimonidine Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression Details Brimonidine Hydromorphone Injection Dilaudid An increased risk of CNS depression Details Brimonidine Hydromorphone Rectal available generically An increased risk of CNS depression Details Brimonidine Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Brimonidine Midazolam Injection Nayzilam An increased risk of CNS depression Details Brimonidine Morphine Injection Astramorph® PF An increased risk of CNS depression Details Brimonidine Nalbuphine Injection Nubain® An increased risk of CNS depression Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.