Brivaracetam

22 interactions 53 cited references
Also sold as: Briviact Briviact®
About Brivaracetam

Brivaracetam is used alone and in combination with other medications to control partial onset seizures (seizures that involve only one part of the brain) in adults, children, and infants 1 month of age and older. Brivaracetam is in a class of medications called anticonvulsants. It works by decreasing abnormal electrica… Read the full Brivaracetam drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ranolazine Voriconazole Nifedipine Lumateperone Hydroxychloroquine Carbamazepine
1 Contraindicated 16 Major 5 Moderate
All (22) Contraindicated (1) Major (16) Moderate (5)

Contraindicated

Brivaracetam Ranolazine Aspruzyo Reduced ranolazine exposure Details

Major

Brivaracetam Atogepant Qulipta Reduced atogepant exposure Details Brivaracetam Cariprazine Vraylar Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Brivaracetam Amlodipine Amvaz® Reduced amLODIPine exposure Details Brivaracetam Alfentanil Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Brivaracetam Calcifediol Rayaldee Altered serum levels of calcifediol Details Brivaracetam Carbamazepine Carbatrol Increased carBAMazepine-10,11 epoxide exposure and an increased risk of carBAMazepine toxicity Details Brivaracetam Cobicistat Tybost Reduced cobicistat exposure Details Brivaracetam Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Brivaracetam Lumateperone Caplyta Reduced lumateperone exposure Details Brivaracetam Nifedipine Adalat® Reduced NIFEdipine exposure Details Brivaracetam Oliceridine Olinvyk Reduced oliceridine exposure and reduced efficacy of oliceridine Details Brivaracetam Orlistat Alli Reduced efficacy of anticonvulsant Details Brivaracetam Pimozide An increased risk of seizure Details Brivaracetam Rifampin Rifadin Decreased brivaracetam plasma concentrations Details Brivaracetam Tramadol ConZip Reduced traMADol exposure and reduced efficacy of traMADol Details Brivaracetam Voriconazole Vfend Reduced voriconazole exposure and an reduced efficacy of voriconazole Details

Moderate

Brivaracetam Artemether Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Brivaracetam Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Brivaracetam Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Brivaracetam Lumefantrine Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Brivaracetam Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.