Bromopride and Acetaminophen And Codeine: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jun 30, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Acetaminophen And Codeine
Bromopride
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Your pain medicine, acetaminophen with codeine, contains an opioid, and opioids can make you sleepy. Bromopride, which is used for nausea and stomach problems, can also cause drowsiness. When you take them together, those two sleepy effects can add up. That could leave you feeling more tired, foggy, or slowed down than usual.
This is mostly a concern based on how these medicines work, not on strong studies, but the sleepiness is still worth taking seriously. The good news is your care team can manage this easily. Please talk with your pharmacist or doctor before taking both, and never stop or change a medicine on your own.
Effect: Additive CNS depression (potentiation of sedative effects) when bromopride is combined with the codeine (opioid) component of acetaminophen/codeine.
- Mechanism: Pharmacodynamic additive sedation; precise mechanism unknown. Both agents have central depressant activity.
- Direction: Increased sedation/CNS depression. This is a PD interaction, not driven by codeine's CYP2D6 activation.
- Evidence/onset: Theoretical; onset unspecified. Severity rated major.
- Management: Documentation advises avoiding concomitant use. If unavoidable, monitor for excess sedation, respiratory depression, and psychomotor impairment; dosing individualized by the care team.
What happens
Potentiation of sedative effects
Interaction Deep Dive
Potentiation of sedative effects may occur with concomitant use of bromopride and opioid analgesics. Avoid concomitant use1.
Why it happens (mechanism)
Unknown
How to manage this interaction
Your care team's main approach here is to avoid using these two together when possible, because the drowsiness from each can add up.
- Keep taking both exactly as prescribed until you speak with your pharmacist or prescriber; do not stop or change anything on your own.
- Ask whether a different nausea or pain option makes sense for you.
- If your team decides you should use both, they may watch you more closely for heavy sedation and adjust doses to fit you.
- Avoid alcohol and other sedating products, and use caution driving until you know how you feel.
Tell your prescriber right away if you feel unusually sleepy, confused, or hard to wake.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Bromopride and Acetaminophen And Codeine together?
Combining bromopride with acetaminophen/codeine can add up their drowsy effects, so the usual advice is to avoid taking them together. Check with your pharmacist or doctor before using both. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Bromopride and Acetaminophen And Codeine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Bromopride and Acetaminophen And Codeine interaction managed?
Your care team's main approach here is to avoid using these two together when possible, because the drowsiness from each can add up. Keep taking both exactly as prescribed until you speak with your pharmacist or prescriber; do not stop or change anything on your own. Ask whether a different nausea or pain option makes sense for you. If your team decides you should use both, they may watch you more… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Bromopride or Acetaminophen And Codeine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: DIGESAN(R) oral capsules, bromopride oral capsules. Sanofi-Aventis Farmaceutica Ltda (per Anvisa), Suzano, Brazil, 2014.
Keep reading about Acetaminophen And Codeine
Keep reading about Bromopride
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