Acetaminophen And Codeine

489 interactions 489 explained in plain English 313 cited references

Also sold as: Capital® & Codeine Codrix® Empracet® (#3, #4) Papa-deine® (#3, #4) Phenaphen® with Codeine (#2, #3, #4) Proval® #3 Tylenol with Codeine Tylenol® with Codeine (#3, #4)

About Acetaminophen And Codeine

The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Codeine belongs to a class of medications cal… Read the full Acetaminophen And Codeine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naltrexone Methylene Blue Mavorixafor Moclobemide Ozanimod Phenelzine

14 Contraindicated 444 Major 26 Moderate 5 Minor

All (489) Contraindicated (14) Major (444) Moderate (26) Minor (5)

Contraindicated

Acetaminophen And Codeine Isocarboxazid Marplan Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Linezolid Zyvox Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Mavorixafor Xolremdi Explained Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Acetaminophen And Codeine Methylene Blue Provayblue Explained Increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Moclobemide Explained Increased risk of serotonin syndrome, increased codeine exposure and reduced active metabolite (morphine) exposure Details Acetaminophen And Codeine Naltrexone ReVia Explained Precipitation of opioid withdrawal symptoms; decreased opioid effectiveness Details Acetaminophen And Codeine Ozanimod Explained Increased risk of serious adverse reactions and an increased risk of serotonin syndrome or opioid-related toxicity Details Acetaminophen And Codeine Phenelzine Nardil Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Procarbazine Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Rasagiline Azilect Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Safinamide Xadago Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Samidorphan Explained Decreased opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Selegiline Anipryl Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Tranylcypromine Parnate Explained Increased risk of serotonin syndrome and an increased risk of CNS depression Details

Major

Acetaminophen And Codeine Abametapir Explained Increased exposure of CYP3A4 substrate Details Acetaminophen And Codeine Abiraterone Acetate Abirtega Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Acetaminophen And Codeine Abiraterone Acetate, Micronized Abirtega Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Acetaminophen And Codeine Acepromazine PROMACE Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Aclidinium Tudorza Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Adagrasib Krazati Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Acetaminophen And Codeine Alfentanil Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Almotriptan Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Alosetron Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Alprazolam Xanax Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Amantadine Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Amifampridine Explained Increased risk of seizures Details Acetaminophen And Codeine Amiloride Explained Reduced diuretic efficacy Details Acetaminophen And Codeine Amineptine Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Amiodarone Nexterone Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Amitriptyline Elavil Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Acetaminophen And Codeine Amitriptylinoxide Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Amobarbital Amytal Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Amoxapine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Acetaminophen And Codeine Amphetamine Dexedrine Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Amprenavir Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Anileridine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Apalutamide Erleada Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Aprepitant Aponvie Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Aripiprazole Abilify Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Aripiprazole Lauroxil Aristada Explained An increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.