Acetaminophen And Codeine and Foslevodopa: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jun 30, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Acetaminophen And Codeine
Foslevodopa
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Your pain medicine contains codeine, an opioid that can make you feel sleepy or slowed down. Foslevodopa, used for Parkinson's symptoms, can also cause drowsiness. When you take both, those calming effects can add up. This might mean feeling more sleepy, dizzy, or foggy than usual, and in some cases slower breathing.
The good news is this is a theoretical concern based on how these drugs work, not something proven to happen often. Your care team can manage it easily by watching how you feel and adjusting things if needed. Just let your pharmacist or doctor know you take both.
Effect: Additive CNS depression when acetaminophen/codeine (opioid component) is combined with foslevodopa.
- Mechanism: Pharmacodynamic additive CNS depression; codeine (opioid) plus dopaminergic therapy, both associated with sedation.
- Direction/magnitude: Increased sedation, dizziness, and potential respiratory depression; magnitude not quantified.
- Onset: Unspecified.
- Evidence: Theoretical; rated major.
Management: Exert caution with coadministration. Monitor for excess sedation, confusion, and respiratory status, particularly in elderly or opioid-naive patients. Doses may need to be individualized by the care team. No PK-based dose adjustment is defined.
What happens
An increased risk of CNS depression
Interaction Deep Dive
Coadministration of foscarbidopa/foslevodopa and CNS depressants may increase risk of CNS depression. Exert caution when coadministered1.
Why it happens (mechanism)
Additive CNS depression
How to manage this interaction
Both medicines can add to each other's calming effect on the brain, so the main strategy is simple awareness and monitoring.
- Keep taking both as prescribed unless your care team tells you otherwise.
- Your team may monitor you more closely for drowsiness, dizziness, confusion, or slowed breathing, especially when you first combine them.
- The opioid dose may need to be adjusted and individualized by your care team.
- Avoid alcohol or other sedating products, and use caution driving until you know how you feel.
Tell your pharmacist or doctor that you take both so they can tailor your plan.
Management is individual — confirm any change with your pharmacist or prescriber.
Literature reports
2 reports — tap to read
Common questions
Can I take Acetaminophen And Codeine and Foslevodopa together?
Taking codeine (in your pain medicine) with foslevodopa can add up to more drowsiness or slowed breathing, so watch for extra sedation and let your care team know you take both. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Acetaminophen And Codeine and Foslevodopa interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Acetaminophen And Codeine and Foslevodopa interaction managed?
Both medicines can add to each other's calming effect on the brain, so the main strategy is simple awareness and monitoring. Keep taking both as prescribed unless your care team tells you otherwise. Your team may monitor you more closely for drowsiness, dizziness, confusion, or slowed breathing, especially when you first combine them. The opioid dose may need to be adjusted and individualized by y… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Acetaminophen And Codeine or Foslevodopa need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: VYALEV(TM) subcutaneous injection, foscarbidopa and foslevodopa subcutaneous injection. AbbVie Inc (per FDA), North Chicago, IL, 2024. DailyMed
- Product Information: Eunerpan(R), Melperonhydrochlorid. Nordmark Arzneimittel GmbH, Uetersen, 1991.
- Product Information: Nipolept(R), zotepine. Klinge Pharma GmbH, Munich, Germany, 1994.
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Keep reading about Foslevodopa
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