Bromopride and Cariprazine: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 16, 2026 · Source data updated Jul 16, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Bromopride
No brand names on recordCariprazine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
These two medicines can add up in a way we want to avoid. Bromopride helps with nausea and stomach movement, and cariprazine (Vraylar) is used for certain mental health conditions. Both can affect the brain pathways that control movement. Taken together, they can raise the chance of what we call extrapyramidal reactions, which are movement problems like stiffness, tremor, restlessness, or unusual muscle spasms.
Because of this, using them at the same time is not recommended. The good news is your care team can manage this easily, usually by choosing a different anti-nausea option. Please don't stop either medicine on your own. Just talk with your pharmacist or doctor so they can sort out the safest plan for you.
Interaction: Additive risk of extrapyramidal symptoms (EPS) when combining bromopride, a dopamine (D2) receptor antagonist prokinetic/antiemetic, with cariprazine, a D2/D3 partial agonist antipsychotic.
- Mechanism: Pharmacodynamic, additive central dopaminergic effects, not a metabolic (PK) interaction.
- Direction/effect: Increased likelihood and severity of EPS (dystonia, akathisia, parkinsonism, and risk of tardive dyskinesia).
- Severity/evidence: Rated contraindicated; substantiation is theoretical.
- Onset: Unspecified.
- Management: Avoid concomitant use; select a non-dopamine-antagonist antiemetic. If already co-prescribed, monitor closely for EPS and consult prescriber.
What happens
Increased risk of extrapyramidal reactions
Interaction Deep Dive
The combined administration of bromopride with additional agents capable of producing extrapyramidal reactions is contraindicated1.
Why it happens (mechanism)
Additive extrapyramidal side effects
How to manage this interaction
What your care team may do:
- Because combining these is not recommended, your prescriber will likely choose a different anti-nausea or stomach medicine that does not affect the same brain pathways.
- If you are somehow taking both, your team may watch you closely for movement side effects.
What you should do:
- Keep taking your medicines as prescribed for now, and do not stop either one on your own.
- Contact your pharmacist or doctor promptly so they can adjust the plan.
- Report any stiffness, tremor, restlessness, or unusual muscle movements right away.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Bromopride and Cariprazine together?
Bromopride and cariprazine both raise the risk of movement side effects and are not recommended together, so contact your pharmacist or doctor to switch to a safer anti-nausea option. Do not stop either drug on your own. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Bromopride and Cariprazine interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Bromopride and Cariprazine interaction managed?
What your care team may do: Because combining these is not recommended, your prescriber will likely choose a different anti-nausea or stomach medicine that does not affect the same brain pathways. If you are somehow taking both, your team may watch you closely for movement side effects. What you should do: Keep taking your medicines as prescribed for now, and do not stop either one on your own. Co… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Bromopride or Cariprazine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: DIGESAN(R) oral capsules, bromopride oral capsules. Sanofi-Aventis Farmaceutica Ltda (per Anvisa), Suzano, Brazil, 2014.
Keep reading about Bromopride
Keep reading about Cariprazine
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist