Budesonide Nasal Spray

221 interactions 609 cited references

Also sold as: Rhinocort Rhinocort® Allergy Spray Rhinocort® Aqua Nasal Spray

About Budesonide Nasal Spray

Budesonide nasal spray is used to relieve sneezing, runny, stuffy, or itchy nose caused by hay fever or other allergies (caused by an allergy to pollen, mold, dust, or pets). Budesonide nasal spray should not be used to treat symptoms (e.g., sneezing, stuffy, runny, itchy nose) caused by the common cold. Budesonide nas… Read the full Budesonide Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mifepristone Levoketoconazole Ensitrelvir Desmopressin Voxelotor Vonoprazan

4 Contraindicated 178 Major 39 Moderate

All (221) Contraindicated (4) Major (178) Moderate (39)

Major

Budesonide Nasal Spray Nimesulide Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Nimesulide Beta Cyclodextrin Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Nirmatrelvir Increased corticosteroid exposure Details Budesonide Nasal Spray Norfloxacin An increased risk of tendon rupture Details Budesonide Nasal Spray Ofloxacin Floxin® An increased risk of tendon rupture Details Budesonide Nasal Spray Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details Budesonide Nasal Spray Omaveloxolone Skyclarys Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Budesonide Nasal Spray Oxaprozin Coxanto Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Oxyphenbutazone Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Palbociclib Ibrance Increased budesonide exposure Details Budesonide Nasal Spray Parecoxib Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Paritaprevir Increased budesonide exposure Details Budesonide Nasal Spray Pazufloxacin An increased risk of tendon rupture Details Budesonide Nasal Spray Pefloxacin An increased risk of tendon rupture Details Budesonide Nasal Spray Phenobarbital Fidoquel Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Budesonide Nasal Spray Phenylbutazone Equi-Phar Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Phenytoin Dilantin Reduced corticosteroid exposure Details Budesonide Nasal Spray Piketoprofen Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Piroxicam Feldene Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Pirtobrutinib Jaypirca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-related adverse effects Details Budesonide Nasal Spray Posaconazole Noxafil Increased budesonide exposure and an increased risk of budesonide-related adverse effects Details Budesonide Nasal Spray Pranoprofen Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Primidone Mysoline Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Budesonide Nasal Spray Proglumetacin Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Propyphenazone Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Proquazone Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Prulifloxacin An increased risk of tendon rupture Details Budesonide Nasal Spray Ranitidine Increased budesonide exposure Details Budesonide Nasal Spray Ranolazine Aspruzyo Increased exposure of CYP3A4 substrate Details Budesonide Nasal Spray Relacorilant Lifyorli Reduced relacorilant exposure and reduced efficacy of relacorilant, altered (reduced/increased) glucocorticoids exposure, reduced... Details Budesonide Nasal Spray Ribociclib Kisqali Increased budesonide exposure Details Budesonide Nasal Spray Ritlecitinib Litfulo Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Budesonide Nasal Spray Ritonavir Norvir Increased budesonide exposure and an increased risk of budesonide-related adverse effects Details Budesonide Nasal Spray Rofecoxib Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Rufloxacin An increased risk of tendon rupture Details Budesonide Nasal Spray Salicylic Acid Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Salsalate Disalcid Increased risk of gastrointestinal ulcer or bleeding Details Budesonide Nasal Spray Saquinavir Increased budesonide exposure and an increased risk of budesonide-related adverse effects Details Budesonide Nasal Spray Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Budesonide Nasal Spray Schisandra Sphenanthera Increased budesonide exposure Details

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