Bumetanide
55 interactions 4 explained in plain English
Also sold as:
Bumex
Enbumyst
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Desmopressin Nasal
Acetaminophen And Codeine
Albuterol Oral Inhalation
Morphine Injection
Gentamicin Ophthalmic
Naproxen
Major
Bumetanide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Bumetanide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Bumetanide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Bumetanide Amikacin Injection Amikin® An increased risk of ototoxicity Details Bumetanide Amikacin Oral Inhalation Arikayce An increased risk of ototoxicity Details Bumetanide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Bumetanide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Bumetanide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Bumetanide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Bumetanide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Foscarnet Injection Foscavir Impaired foscarnet elimination and potential for toxicity Details Bumetanide Gentamicin Injection Garamycin® I.V. An increased risk of ototoxicity Details Bumetanide Gentamicin Ophthalmic Garamycin® Ophthalmic An increased risk of ototoxicity Details Bumetanide Gentamicin Topical Garamycin® An increased risk of ototoxicity Details Bumetanide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Bumetanide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Bumetanide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Lithium Carbonate Lithobid An increased risk of lithium toxicity Details Bumetanide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Bumetanide Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Bumetanide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Bumetanide Morphine Injection Astramorph® PF Reduced efficacy of diuretics DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.