Buprenorphine

633 interactions 533 explained in plain English 652 cited references

Also sold as: Belbuca Brixadi Buprenex BuTrans Simbadol Sublocade Zorbium

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Ensitrelvir Posaconazole Piperaquine Pimozide Phenelzine

22 Contraindicated 601 Major 10 Moderate

All (633) Contraindicated (22) Major (601) Moderate (10)

Major

Buprenorphine Perazine Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Periciazine Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Perphenazine Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Buprenorphine Phenobarbital Fidoquel Explained An increased risk of QT interval prolongation, an increased risk of CNS depression, reduced buprenorphine exposure and reduced eff... Details Buprenorphine Phenytoin Dilantin Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Pimavanserin Nuplazid Explained An increased risk of QT interval prolongation Details Buprenorphine Pinazepam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Pipamperone Explained An increased risk of QT interval prolongation Details Buprenorphine Pipenzolate Bromide Explained An increased risk of paralytic ileus Details Buprenorphine Piperacetazine Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Pipotiazine Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Pirenzepine Explained An increased risk of paralytic ileus Details Buprenorphine Piretanide Explained Reduced efficacy of diuretics Details Buprenorphine Piritramide Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Buprenorphine Pitolisant Wakix Explained An increased risk of QT interval prolongation Details Buprenorphine Polythiazide Explained Reduced efficacy of diuretics Details Buprenorphine Ponesimod Ponvory Explained An increased risk of QT interval prolongation Details Buprenorphine Potassium Oxybate Xywav Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Buprenorphine Prazepam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Prednisone Deltasone Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Pregabalin Bonqat Explained An increased risk of respiratory depression Details Buprenorphine Primidone Mysoline Explained An increased risk of QT interval prolongation, an increased risk of CNS depression, reduced buprenorphine exposure and reduced eff... Details Buprenorphine Probucol Explained An increased risk of QT interval prolongation Details Buprenorphine Procainamide Procan® Explained An increased risk of QT interval prolongation Details Buprenorphine Procarbazine Explained An increased risk of serotonin syndrome or opioid-related toxicity Details Buprenorphine Prochlorperazine Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Buprenorphine Procyclidine Explained An increased risk of paralytic ileus Details Buprenorphine Promazine Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Promethazine Phenadoz Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Buprenorphine Propafenone Rythmol Explained An increased risk of QT interval prolongation Details Buprenorphine Propantheline Probanthine Explained An increased risk of paralytic ileus Details Buprenorphine Propiverine Explained An increased risk of paralytic ileus Details Buprenorphine Propofol Diprivan Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Protriptyline Explained An increased risk of QT interval prolongation, an increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Buprenorphine Quazepam Doral Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Quetiapine Seroquel Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Buprenorphine Quinethazone Explained Reduced efficacy of diuretics Details Buprenorphine Quinidine Cardioquin® Explained An increased risk of QT interval prolongation Details Buprenorphine Quinine Explained An increased risk of QT interval prolongation Details Buprenorphine Quizartinib Vanflyta Explained An increased risk of QT interval prolongation Details

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