Buprenorphine
633 interactions 533 explained in plain English 652 cited references
Also sold as:
Belbuca
Brixadi
Buprenex
BuTrans
Simbadol
Sublocade
Zorbium
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Moderate
Buprenorphine Brimonidine Alphagan Explained An increased risk of CNS depression Details Buprenorphine Carbachol Isopto Carbachol Explained An increased risk of CNS depression Details Buprenorphine Clonidine Duraclon Explained An increased risk of sedation and somnolence Details Buprenorphine Desmopressin DDAVP Explained Increased risk of water intoxication with hyponatremia Details Buprenorphine Ganaxolone Ztalmy Explained An increased risk of somnolence and sedation Details Buprenorphine Mavacamten Camzyos Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Buprenorphine Rilzabrutinib Wayrilz Explained Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Buprenorphine Grapefruit Juice Explained Increased plasma concentrations of buprenorphine Details Buprenorphine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Buprenorphine Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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