Quinine and Buprenorphine: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Buprenorphine
Quinine
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Both of these medicines can affect your heart's rhythm. Buprenorphine (a pain and addiction medicine) and quinine can each slightly stretch out a part of your heartbeat called the QT interval. When you take them together, that effect may add up, and in rare cases a very long QT can trigger a dangerous irregular heartbeat.
To be clear, this is a theoretical concern, meaning it is based on how the drugs work rather than lots of reports. The risk goes up if you have things like low potassium or magnesium, a slow heartbeat, or heart problems. Please don't change anything on your own. Let your pharmacist or doctor know you take both so they can keep you safe.
Mechanism: Additive QT interval prolongation. Both buprenorphine and quinine are independently associated with QT prolongation; neither is a prodrug, so this is a pharmacodynamic (additive) effect, not a metabolic one.
- Direction/effect: Increased risk of QT prolongation and, potentially, torsades de pointes.
- Evidence: Theoretical; combined risk not quantified.
- Onset: Unspecified.
- Management: Avoid concomitant use where possible. If co-prescribed, assess baseline QT, correct hypokalemia/hypomagnesemia, and consider ECG monitoring. Use added caution with bradycardia, CHF, recent AF conversion, digitalis therapy, or congenital long-QT.
What happens
An increased risk of QT interval prolongation
Interaction Deep Dive
The simultaneous use of buprenorphine along with medications capable of extending the QT interval should be avoided 342. It remains unknown what risk arises when buprenorphine is paired with other agents that prolong QT prolongation. When prescribing buprenorphine, clinicians should factor these observations into their decisions for patients who carry risk factors, including hypokalemia, bradycardia, a recent conversion from atrial fibrillation, congestive heart failure, treatment with digitalis, baseline QT prolongation, subclinical long-QT syndrome, or severe hypomagnesemia 1.
Why it happens (mechanism)
Additive QT interval prolongation
How to manage this interaction
The goal here is to protect your heart rhythm. Guidance is to avoid using buprenorphine and quinine together when possible, but your care team can manage this if both are needed.
- Keep taking both exactly as prescribed unless your prescriber tells you otherwise.
- Your team may check an ECG and your potassium and magnesium levels, and monitor you more closely.
- Tell them if you have heart failure, a slow or irregular heartbeat, or a family history of long-QT syndrome.
- Report fainting, palpitations, or dizziness promptly.
Ask your pharmacist or doctor whether an alternative to one of these is a better fit for you.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Quinine and Buprenorphine together?
Buprenorphine and quinine can each prolong the QT interval, so combining them may add to that risk; this is a theoretical major concern, and your care team may prefer to avoid the combination or monitor your heart rhythm and electrolytes closely. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Quinine and Buprenorphine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Quinine and Buprenorphine interaction managed?
The goal here is to protect your heart rhythm. Guidance is to avoid using buprenorphine and quinine together when possible, but your care team can manage this if both are needed. Keep taking both exactly as prescribed unless your prescriber tells you otherwise. Your team may check an ECG and your potassium and magnesium levels, and monitor you more closely. Tell them if you have heart failure, a s… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Quinine or Buprenorphine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (4)
- Product Information: BRIXADI(TM) subcutaneous extended-release injection, buprenorphine subcutaneous extended-release injection. Braeburn Inc (per FDA), Plymouth Meeting, PA, 2023. DailyMed
- Product Information: BUTRANS(R) transdermal system patch, buprenorphine transdermal system patch. Purdue Pharma L.P. (per FDA), Stamford, CT, 2016. DailyMed
- Product Information: BELBUCA(TM) buccal film, buprenorphine buccal film. Endo Pharmaceuticals Inc. (per FDA), Malvern, PA, 2016.
- Product Information: BUPRENEX(R) intravenous injection, intramuscular injection, buprenorphine HCl intravenous injection, intramuscular injection. Indivior Inc. (per DailyMed), Richmond, VA, 2016. DailyMed
Keep reading about Buprenorphine
Keep reading about Quinine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist